This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.  Read our Cookies Policy.
Close
Eye News
  • Features
    • Close
    • Features
    • Allied Professions
    • Humanitarian
    • Interviews
    • AI & Oculomics
    • Ophthalmology
    • Optometry
    • Podcast videos
    • Supplements
  • Education
    • Close
    • Education
    • Learning Curve
    • Quiz
    • Top Tips
    • Trainees
    • Medico-Legal
    • The Truth Behind The Headlines
    • Case Reports
    • Pete's Bogus Journey
  • Reviews
    • Close
    • Reviews
    • Book Reviews
    • Journal Reviews
    • What's trending?
    • Tech Reviews
    • My Top Five
    • The Culture Section
  • Events
  • News
  • Product Guide
  • Industry News
  • Contact us
    • Close
    • Contact us
    • Write for Eye News
  • Home
  • Reviews
  • Journal Reviews
  • Oral azithromycin for meibomian gland disease

Oral azithromycin for meibomian gland disease
Reviewed by Anjali Gupta

1 October 2016 | Anjali Gupta | EYE - Cornea, EYE - General

Oral tetracyclines have been the traditional systemic treatment of blepharitis and acne rosacea, through inhibiting bacterial lipase production and reducing fatty acids. However, tetracyclines have a number of adverse side-effects and are required to be taken for a long duration of time, meaning that poor compliance may be an issue amongst patients. Azithromycin is a semi synthetic macrolide, related to erythromycin. It has good intracellular penetration and a long half-life, therefore providing an effective antimicrobial, antioxidant and a favourable immunomodulatory effect without the compliance issues of long-term tetracycline use. The authors performed a retrospective case audit over a one year time period for patients prescribed 500mg oral azithromycin once daily for three days. Eleven patients were included in the study. Nine patients had a diagnosis of meibomian gland disease / acne rosacea and four had dry eye syndrome. Seventy-three percent of participants had previously trialled a three month course of tetracyclines. All patients were reviewed two to three months post azithromycin treatment. No compliance issues were reported in all 11 participants. Eight patients reported a subjective improvement in their ocular surface symptoms, with the remaining three reporting no change. Seven patients had an improvement in one line of best corrected visual acuity (BCVA) compared with their last review. An objective improvement of the ocular surface and lid margin was seen in nine patients. In conclusion, more research is needed to see if oral azithromycin will displace the tetracyclines and become the first line systemic treatment of meibomian gland disease in the adult population in the future. 

Oral azithromycin as the systemic treatment of choice in the treatment of meibomian gland disease.
Al-Hity A, Lockington D.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
2016;44:199-200
Share This
CONTRIBUTOR
Anjali Gupta

Birmingham and Midland Eye Centre, Birmingham, UK.

View Full Profile
Specialty
  • EYE - Cataract
  • EYE - Cornea
  • EYE - General
  • EYE - Glaucoma
  • EYE - Neuro-ophthalmology
  • EYE - Oculoplastic
  • EYE - Oncology
  • EYE - Orbit
  • EYE - Paediatrics
  • EYE - Pathology
  • EYE - Refractive
  • EYE - Strabismus
  • EYE - Vitreo-Retinal
Archive
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013

Top Of Page

9 Gayfield Square, 
Edinburgh EH1 3NT, UK.

Call: +44 (0)131 557 4184
www.pinpoint-scotland.com

WEBSITE DETAILS
  • Cookie Policy
  • Data Protection Notice
  • Privacy Policy
  • Terms and Conditions
ABOUT US
  • Who we are
  • Register
  • Contact us
  • Contributors
  • Company Awards
DIGITAL ISSUES/GUIDELINES
  • Digital issues - Library
  • Supplements - Library
  • Guidelines
Accreditations
IPSO_FLAG_TEAL 2025.png cpdcertified.png

Pinpoint Scotland Ltd (Registered in Scotland No. SC068684) | © 2025 - Website by Gecko Agency