Ocular findings in children with myasthenia
Reviewed by Ivan Yip

This is a retrospective audit of paediatric myasthenic patients presenting to Great Ormond Street (GOSH) between January 2016 and January 2020. During this period there were 49 children, including 27 with juvenile myasthenia (JMG) and the rest as congenital myasthenia (CMG). There was an increased female preponderance of 75%. Anti-acetylcholine receptor antibodies were positive in 81% of the JMG cohort and all CMG patients had identified genetic mutations in keeping with CMG. Ptosis was the main presenting symptom at 65%, 18% with squint. Pyridostigmaine was the drug of choice in 67% of patients. Oral steroids were used as a rescue treatment. None of the patients required surgery for ptosis. Amblyopia relating to strabismus or ptosis was rare and only 3% had residual amblyopia following treatment. This paper usefully summarises GOSH myasthenic paediatric patients giving readers further information about the prognosis of this rare condition.

Demographic and ocular findings in children with myasthenia.
Arruti N, Munot P, Bowman R.
EYE
2023;37:700-4.