This study compared optical coherence tomography (OCT) data of fellow and amblyopic eyes, and reported OCT changes after long-term electronically monitored occlusion therapy. The study recruited 30 patients with mean age of 16.7 ±11.2 years (range 5.1–44.7 years): 53% males. There were 4 strabismic, 16 anisometropic and 10 mixed amblyopia cases. Average spherical equivalent refraction of the amblyopic eye was +2.29 ±3.25D (range -4.75 to +6.75D). For the fellow eye, this was +1.6 ±2.1D (range -2.25 to +5.75D). Best corrected visual acuity was 0.50 ±0.36logMAR for the amblyopic eye and 0.03 ±0.12 for the fellow eye. Macular 3D scan measured amblyopic eye average thickness as 282.0 ±13.0µm, centre thickness as 204.9 ±30.8µm and total volume as 7.98 ±0.37mm3. For the fellow eye, amblyopic eye average thickness was 278.6 ±13.3µm, centre thickness as 197.3 ±26.4µm and total volume as 7.88 ±0.38mm3. There was minimal significant difference (p=0.0495) for average thickness and total volume measurements between eyes, being marginally higher in amblyopic eyes. Variables significantly decreased in amblyopic eyes after occlusion. The trend for this was also seen in the fellow eye. Those with moderate to severe amblyopia showed greater interocular difference and greater change after occlusion. Longer periods of occlusion appeared to result in more monocular thinning in the amblyopic eye. Structural changes also occurred in the fellow eye. The authors acknowledge this was a pilot study and larger case numbers are needed along with a control group in future studies.
OCT changes after occlusion therapy in amblyopic and fellow eyes
Reviewed by Fiona Rowe
Optical coherence tomography (OCT) parameters in amblyopia.
CONTRIBUTOR
Fiona Rowe (Prof)
Institute of Population Health, University of Liverpool, UK.
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