This was a non-inferiority prospective randomised controlled trial to compare efficacy and safety of microdrops over standard dose mydrin-P in retinopathy of prematurity (ROP) screening, and to determine optimal time for eye examination after administration of drops. The trial included 18 infants with record of 46 ROP examinations with 23 having standard drops and 23 having microdrops. Dark irides were present in 82.6% and light in 17.4%. One infant had advanced ROP stage 3 with plus disease. Average duration from first dose to eye examination was 97.83 minutes (standard dose) and 99.61 minutes for microdrops (not significant). All infants with microdrops had successful ROP examination. 3 infants in the standard group failed examinations; defined as inadequate pupil size after drops. Mean pupil diameter was not significantly different between groups. There were no significant differences for heart rate, mean blood pressure, side effects or oxygen saturation for groups. The authors conclude microdrops achieved adequate pupil dilation for successful eye examination and can replace standard dose mydrin-P. This potentially mitigates side effects of mydriasis by reducing exposure to the drug by two-thirds.
Mydrin-P microdrops vs mydrin-P standard drops for ROP examination
Reviewed by Fiona Rowe
Randomised controlled trial comparing the efficacy of mydrin-P microdrops over standard dose mydrin-P for pupil dilation in retinopathy of prematurity examination.
CONTRIBUTOR
Fiona Rowe (Prof)
Institute of Population Health, University of Liverpool, UK.
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