A case report is presented of a patient with treated retinoblastoma (RB) who later developed asteroid hyalosis which mimicked tumour seeding. The case was a 37-year-old male with presenting symptoms of vitreous floaters. A unilateral RB was diagnosed at the age of 12 and treated with laser photocoagulation and plaque radiotherapy. On examination, signs indicated RB recurrence with vitreous seeding. Further evaluation with scans and OCT showed presence of regressed tumour scar and uniform, homogenous, calcified deposits on clinical examination with ultrasound supported diagnosis of asteroid hyalosis. Continued monitoring for 66 months showed no change.