This is a prospective, longitudinal, observational single centre study between May 2011 and September 2018, to determine the changes in the axial length (AL) longitudinally in patients with high myopia without other conformational abnormalities. Patients were divided into two groups: a high myopia group of 60 eyes (AL > or = to 26mm) and a control group (60 eyes: AL < 26mm, spherical equivalent (SE) between +3.0 to -6.0). Both groups were further subdivided into four subgroups according to AL: Subgroup A (AL > or= 27.5mm), B (AL 26 to 27.5mm), C (AL 24.5 to 26mm) and D (AL <24.5mm). IOL Master was used for measuring the AL, anterior chamber depth and corneal curvature radius five times at one-yearly intervals. In the high myopia group, the AL showed a significant relatively constant increase at most visits but not in the control group. Subgroups A, B and C showed significant changes in AL over time (0.064, 0.032 and 0.012mm/yr, respectively). Only baseline AL was significant (p<0.001) in multivariate analysis. The authors concluded that myopic eyes (including moderate myopia), showed constant increase in AL over the four-year period. Eyes with longer baseline AL showed a greater increase in AL than eyes with a shorter AL. The limitations of the study include relatively younger patients in this group and SE was not studied during the follow-up period.
Longitudinal changes in axial length in high myopia
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