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The efficacy, recurrence rate and requirement for additional treatment were compared between laser photocoagulation and IVT of 1mg/0.025ml aflibercept in the treatment of retinopathy of prematurity (ROP). The study included 27 babies (51 eyes) who completed a follow-up period after treatment. The laser group included 27 eyes of 15 babies; 252 eyes at stage 3 and two eyes at stage 2. The IVT group included 24 eyes of 12 babies; 14 eyes at stage 3 and 10 eyes with aggressive post ROP (APROP). There were no treatment related complications for either group. Regression rates after treatment were 92.6% and 100% respectively for laser and IVT. Recurrence rate was 30% in the laser group and 25% of all eyes treated for recurrence. Ten patients with IVT required laser photocoagulation treatment during follow-up. The authors conclude that IVT with aflibercept is an effective treatment. However, it needs more additional treatment during follow-up than the laser photocoagulation group.

Comparison of the efficacy between intravitreal aflibercept and laser photocoagulation in the treatment of ROP.
Ekinci DY, Celik K.
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Fiona Rowe (Prof)

Institute of Population Health, University of Liverpool, UK.

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