The authors describe how three patients with retinal pigment epithelium (RPE) detachment showed a reduction or disappearance of an RPE detachment immediately following prone dark room test (PDRT). The authors performed spectralis OCT on 140 angle closure subjects before and after PDRT. Three patients showed a flattening or complete resolution of the RPE detachment with an acute rise and then fall in IOP. The authors describe the occurrence with short-term IOP changes only but further studies are needed to explore the concept and factors influencing such changes.