In this study the authors made a comparison of significant postoperative tilt of IOL with air tamponade as opposed to balanced salt solution, in the procedure of combined phaco with IOL and vitrectomy. Thirty-four patients were included into the analysis. Thirty-one were scheduled for surgery due to idiopathic epiretinal membranes (ERMs), two eyes due to ERMs and diabetic macular oedema and one eye due to vitreous haemorrhage. Right eye to left eye distribution was 11:23. Female-to-male distribution 18:16. The mean age was 71.3 years (range: 53-82 years). Thirteen eyes received balanced salt solution and 21 received air tamponade. Twenty-eight eyes received a Tecnis ZCB00 (Johnson & Johnson, USA), three patients an AT TORBI 709MP (Carl Zeiss Meditec, Germany), two patients a CT Asphina 409MP (Carl Zeiss Meditec, Germany) and one patient a CT Lucia 601P (Carl Zeiss Meditec, Germany). Tilt of the IOL, measured with a Purkinje meter two months after surgery was on average 4.1±1.9° (median: 4.1°; range: 1.7-7.7°) without significant differences between balanced salt solution and air tamponade (p=0.462). Decentration of the IOL was on average 0.31±0.14mm, without significant differences between the two groups (p=0.42). Limitations: Small sample size.