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This retrospective study between 2008 and 2019 of 110 eyes with primary open angle glaucoma (POAG), 33 eyes with ocular hypertension (OHT) and 43 eyes with uveitic glaucoma (UG) evaluated the changes in intraocular pressure (IOP) following topical ocular hypotensive medications (TOHM) washout in these three groups of patients. All patients had one month washout period from TOHM before IOP phasing and comparisons were made pre washout IOP, peak IOP and post washout IOP. The mean increase in IOP was significantly lower in the UG group compared with POAG and OHT groups (p=0.01). The percentage of post washout eyes with IOP <21mmHg was 12.7% in POAG, 6.1% in OHT and 51.2% in UG. The authors concluded that IOP may return to normal once inflammation resolves and recommend TOHM washout to be considered in UG patients that have IOP under control in the absence of active inflammation. The limitations include no fixed control of IOP treatment protocol, all TOHM were stopped at the same time, heterogeneity of UG patients, variable duration of steroids drops treatment and retrospective nature of recording the peak IOP data in the study.


Intraocular pressure changes following topical ocular hypotensive medications washout.
Ho H, Daas A, Ho J, et al.
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Jonathan Chan

Royal Hallamshire Hospital, Sheffield, UK.

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