This is a systematic review of 12 papers, which included 8688 participants and identified 202 cases of incidental ocular surface squamous neoplasia (OSSN) (pooled prevalence=1.32%, 95% confidence interval (CI), I2=95.3%). Meta-regression showed that lower OSSN prevalence was associated with greater distance from equator (odds ratio 0.49, 95% CI, p=0.01). Regional analyses revealed variation in prevalence: Europe (0.29%), Asia (0.76%), North America (1.03%), Oceania (8.57%) and South America (14.97%). The authors concluded that the overlap in demographic and lesion characteristics between benign and pterygia and OSSN underscores diagnostic challenges.
Incidental ocular surface squamous neoplasia in pterygia: a systematic review and meta-analysis
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