High myopes with POAG and IOP fluctuations
Reviewed by Lorraine North

The authors describe a prospective study of 80 eyes of Chinese patients with primary open-angle glaucoma (POAG) on prostaglandin analogues to investigate if those who also have high myopia exhibit greater short-term intraocular pressure (IOP) fluctuations at resting conditions over 24 hours and after dynamic exercise. The authors used two protocols for IOP measurement by the same technician. Protocol 1 required all patients to be hospitalised and asked to maintain a supine position for 15 months before the start of the test; measurements were then taken at 8am, 10am, 2pm, 6pm, 10pm, 2am and 6am using pneumatonometer in the sitting position. Protocol 2 examined the IOP after dynamic exercise on the patients after a three day break from protocol 1. IOP was measured using Goldmann applanation tonometry. Their results showed that there was no difference between 24 hour fluctuations at resting conditions for both groups. However, they found a significant IOP fluctuation in patients with POAG and high myopia and the exercise test but the IOP decreased in this group particularly after rapid running compared to other POAG patients. The authors acknowledged the limitation in this study as IOP was measured in protocol 1 using a noncontact pneumatonometer which is not as accurate as Goldman tonometry. 

Intraocular pressure fluctuations in patients with primary open-angle glaucoma combined with high myopia.
Yang Y, Li Z, Wang N, et al.
JOURNAL OF GLAUCOMA
2014;23(1):19-22.