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This retrospective study examined fluorescein angiography (FA) images of 162 eyes of 81 treatment-naive infants with retinal vascular immaturity and persistent avascular retina (PAR) despite exceeding postmenstrual age of 60 weeks. Disc diameter (DD), optic disc-to-fovea distance (FD), the length of temporal retinal vascularisation (LTRV), and the length of measurable temporal avascular retina distance (LMTAR) were analysed. Mean gestational age and FA imaging age were 29.39 ±3.13 and 86.51 ±24.80 weeks. Mean ratios of mLTRV/FD and LMTAR /DD were 4.47 ±0.36 and 2.21 ±1.01, respectively. Pigmentary changes were detected in the peripheral retina in 21% of the eyes. At least one angiographic feature was identified in 88% of the eyes. Based on the FA findings, laser photocoagulation was performed to the peripheral avascular retina in 10 eyes of five patients. Even in larger preterm infants and without severe retinopathy and anti-VEGF treatment, PAR and peripheral pigmentary changes may be detected, and mild angiographic vascular activity may continue. The authors highlight that these findings may lead to late-onset retinal pathologies that may threaten vision and with PAR, the authors recommend follow-up with FA and prophylactic laser may be required.

Fluorescein angiography findings in treatment-naive premature infants with retinal vascular immaturity and persistent avascular retina.
Bayramoglu SE, Sayin N.
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Su Young

Moorfields Eye Hospital NHS Trust, London, UK.

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