This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.  Read our Cookies Policy.
Close
Eye News
  • Features
    • Close
    • Features
    • Allied Professions
    • Humanitarian
    • Interviews
    • AI & Oculomics
    • Ophthalmology
    • Optometry
    • Podcast videos
    • Supplements
  • Education
    • Close
    • Education
    • Learning Curve
    • Quiz
    • Top Tips
    • Trainees
    • Medico-Legal
    • The Truth Behind The Headlines
    • Case Reports
    • Pete's Bogus Journey
  • Reviews
    • Close
    • Reviews
    • Book Reviews
    • Journal Reviews
    • What's trending?
    • Tech Reviews
    • My Top Five
    • The Culture Section
  • Events
  • News
  • Product Guide
  • Industry News
  • Contact us
    • Close
    • Contact us
    • Write for Eye News
  • Home
  • Reviews
  • Journal Reviews
  • Efficacy and safety of novel PF brimonidine / timolol fixed-combination ophthalmic solution for OAG

Efficacy and safety of novel PF brimonidine / timolol fixed-combination ophthalmic solution for OAG
Reviewed by Su Young

4 August 2021 | Su Young | EYE - Glaucoma | Open-angle glaucoma, brimonidine/timolol fixed combination, intraocular pressure, normal-tension glaucoma, preservative-free
Share This

This study is a multicentre, randomised, open-label, parallel-group clinical trial to evaluate the efficacy and safety of a newly developed preservative-free (PF) brimonidine / timolol fixed-combination (BTFC) ophthalmic solutions as compared with preservative-containing (PC) BTFC ophthalmic solution in adult patients (aged ≥19 years) with open-angle glaucoma (OAG) and ocular hypertension (OHT). A total of the 106 patients were enrolled, with 53 patients each randomised to the two treatment groups and included in the analysis of the safety set (SS). Patients with an IOP below 35mmHg at 9am were enrolled following washout period. A total of 106 OAG and OHT patients were randomised to the PF group or PC group. All subjects were examined four and 12 weeks after first administration. At each follow-up visit, IOP was measured at 9am and 11am and the efficacy, safety and compliance were evaluated. Results: The mean IOP changes from baseline to 12 weeks at 11am were −3.45 ±2.53mmHg in the PF group and −3.65 ±2.76mmHg in the PC group (p<.0001 for both). The difference in mean IOP change between the two groups was 0.20 ±2.65mmHg, which was not significantly different. The proportion of patients with IOP reductions of ≥15% and ≥20% and IOP at all-time points in the PF group were not significantly different when compared with in the PC group. There were no specific differences between the two groups regarding the incidence of adverse events, with only one patient (one case) in the PF group developing corneal erosion. In the PC group, corneal abrasion and vitreous haemorrhage were reported in one patient (one case) each. The authors conclude that PF BTFC ophthalmic solution shows a similar efficacy and safety profile to that of PC BTFC.

Comparison of the intraocular pressure-lowering effect and safety of preservative-free and preservative-containing brimonidine/timolol fixed-combination ophthalmic solutions in patients with open-angle glaucoma.
Joon Mo Kim, Tae-Woo Kim, Sang-Woo Park, et al.
SEMINARS IN OPHTHALMOLOGY
2021;36(3):103-9.
Share This
Su Young
CONTRIBUTOR
Su Young

Tennent Institute of Ophthalmology, NHS Greater Glasgow and Clyde, UK.

View Full Profile
Specialty
  • EYE - Cataract
  • EYE - Cornea
  • EYE - General
  • EYE - Glaucoma
  • EYE - Neuro-ophthalmology
  • EYE - Oculoplastic
  • EYE - Oncology
  • EYE - Orbit
  • EYE - Paediatrics
  • EYE - Pathology
  • EYE - Refractive
  • EYE - Strabismus
  • EYE - Vitreo-Retinal
Archive
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013

Top Of Page

9 Gayfield Square, 
Edinburgh EH1 3NT, UK.

Call: +44 (0)131 557 4184
www.pinpoint-scotland.com

WEBSITE DETAILS
  • Cookie Policy
  • Data Protection Notice
  • Privacy Policy
  • Terms and Conditions
ABOUT US
  • Who we are
  • Register
  • Contact us
  • Contributors
  • Company Awards
DIGITAL ISSUES/GUIDELINES
  • Digital issues - Library
  • Supplements - Library
  • Guidelines
Accreditations
IPSO_FLAG_TEAL 2025.png cpdcertified.png

Pinpoint Scotland Ltd (Registered in Scotland No. SC068684) | © 2025 - Website by Gecko Agency