Effect of trabeculectomy on corneal endothelial cell loss
Reviewed by Jonathan Chan

This is a prospective study of 117 eyes for two years after trabeculectomy, to investigate the corneal endothelial cell density (CECD) by specular microscopy prior to and after surgery on a six monthly basis. At six, 12, 18 and 24 months after surgery, the results of the Kaplan-Meier survival analysis of 10% loss of CECD from baseline were 91%, 85%, 83% and 77% respectively. Uveitic glaucoma was a significant factor for decreasing CECD (p=0.041). The authors concluded that CECD decreased significantly and continuously post trabeculectomy. The limitations of this study are the location of the cornea area sampled at each visit post-surgery, only the central cornea CECD was measured but not near the bleb location and future prospective study for multiple cornea areas are required.

Effect of trabeculectomy on corneal endothelial cell loss.
Hirooka K, Nitta E, Ukegawa K, et al.
BRITISH JOURNAL OF OPHTHALMOLOGY
2020;104:376-80.