Central retinal vein occlusion is the second most common retinal vascular disorder after diabetic retinopathy. There are many studies reporting the efficacy of intravitreal anti-VEGF injections for macular oedema secondary to retinal vein occlusions. This paper looks at the contrast sensitivity change after single injection of Avastin in patients with macular oedema secondary to central retinal occlusion. Sixteen eyes were included in the study. Contrast sensitivity, best-corrected visual acuity (BCVA), foveal thickness (FT) and macular volume (MV) were recorded before and after treatment with single injection of Avastin. Contrast sensitivity significantly improved at spatial frequencies – 1.5, 3, 6, 12 and 18 cycles per degree (cpd) – one month after the injection and six cpd at three month follow-up. BCVA, FT and MV also improved.