Contact lenses for adults with infantile nystagmus
Reviewed by Fiona Rowe

A pilot randomised controlled trial (RCT) was conducted to determine recruitment rates, acceptability of and adherence to treatment and adverse events along with change in best corrected visual acuity (BCVA) and nystagmus parameters from baseline to two weeks follow-up. The authors compared fully corrective soft contact lenses with plano soft contact lenses (plus spectacle correction if required). The trial recruited adults with idiopathic infantile nystagmus who were randomised on a 1:1 ratio for 38 participants. Patients were recruited direct from ophthalmology clinics; 19 to each group. Twenty-seven completed the trial; 16 in the plano group and 11 in the corrected contact lens group. Four withdrawals were failures to insert their contact lenses despite teaching sessions. Seven were lost to follow-up. Adverse events included contact lens discomfort reported by three patients and three cases of contact lens tearing. Visual acuity measures were reported for 27 completers. Mean increase in BCVA at two weeks was 0.07 for the plano group and 0.06 for the corrected contact lens group – this was not significant. Nystagmus parameters improved in both groups. The sample size calculation for future trials was 40 to detect 0.1logMAR difference in groups at 90% power.

Soft contact lenses to optimise vision in adults with idiopathic infantile nystagmus; a pilot parallel RCT.
Theodorou M, Quartilho A, Xing W, et al.
STRABISMUS
2018;26(1):11-21.