This longitudinal cohort study aimed to report the clinical features, treatment strategy, and mortality of 15 consecutive patients (16 eyes) with endogenous panophthalmitis (EP) at a tertiary medical centre of the largest eye centre in Northern China. Mean age was 58.3 years and 62.5% were male. The mean follow-up duration was 12.5 (range, 6–24) months. Presenting visual acuity was light perception or worse in all patients except for one (hand movements) and the chief ocular presenting complaint was decreased vision and ocular pain. Only four eyes were eligible for vitrectomy. Patients on average had three predisposing factors. The top two predisposing factors were diabetes mellitus (DM, 93.3%) and pyogenic liver abscess (PLA, 66.7%). All patients were admitted with emergency ocular symptoms and were managed jointly with other specialties for systemic complications. Thirteen patients recorded pyrexia (above 38°C) at presentation. The mortality rate was 0%. The predominant causative organism was Klebsiella pneumoniae (80.0%) and there were no positive fungal cases. The authors conclude that EP is a rare, life-threatening disease and DM and PLA could predispose its development. Interdisciplinary cooperation for the management of EP was recommended for favourable mortality rates.