This study measured the impact of amblyopia treatment (patching and atropine) on health-related quality of life from the child’s perspective using the Child Amblyopia Treatment Quality of Life (CATQoL) questionnaire. The study recruited 46 children with no treatment in the two-month period prior to study enrolment. Two groups consisted of patching (61%) versus atropine (39%). The atropine group had children with poorer visual acuity. Age was similar across both groups. Children also completed the PEDSQL questionnaire – the scores of this questionnaire did not change significantly after four weeks of treatment. The same occurred for the CATQoL scores. Parents and children chose their treatment options and the findings suggest that offering this choice as the first-line treatment for amblyopia is appropriate, as children tolerated both equally well.