Characteristics of central serous chorioretinopathy by age
Reviewed by Ian Reekie

The authors present a cohort study of 326 patients with simple central serous chorioretinopathy (CSC) according to the classification system laid down by Chhablani, et al. in 2020. Genotyping for two variants of the CFH gene rs800292 and rs1329428 was undertaken, and clinical parameters including subfoveal choroidal thickness, central retinal thickness and OCT and indocyanine green angiography findings were recorded. The authors employed multivariate regression analyses to test the association of variables of interest with age of onset of CSC. The study demonstrated that there was a statistically significant correlation between younger age and thicker subfoveal choroidal thickness, male sex and the T allele at CFH rs1329428. A possible conclusion to draw from this work, that the authors allude to briefly, is the possibility that CSC may have different pathogenesis at different ages. An extension of this conclusion would be that there are therefore different treatment strategies to be sought for these different CSC entities. A key omission of this work is the exclusion of any patient who had received topical or systemic corticosteroids. Corticosteroid use is a well-known risk factor for CSC, and so the exclusion of these patients limits the generalisability and clinical relevance of these findings. The authors also declare the omission of an initial power calculation, so it is not clear if the study is powered to detect weaker associations.

Clinical and genetic characteristics of simple central serous chorioretinopathy according to age.
Shijo T, Fukui A, Sakurada Y, et al.
OPHTHALMIC GENETICS
2025;46(1):25–30.