Assessment of retinal capillary VD and FAZ area in CSC using OCTA
Reviewed by Sofia Rokerya

The authors aim to report a cross-sectional, case controlled study, the purpose of which was to access the retinal capillary vessel density (VD) and foveal avascular zone (FAZ) area in acute and chronic central serous chorioretinopathy (CSC) patients compared to healthy subjects using OCTA 3x3mm images, and determine their correlation with visual acuity (VA). A total of 148 subjects (148 eyes) were included in this study, with 50 eyes in acute CSC, 48 eyes in chronic CSC, and 50 eyes in control groups. The mean age was 50.11 ±8.14 years. There were 89 male and 59 female subjects. Acute CSC, chronic CSC and control subjects were sex and age matched. At baseline, chronic CSC had a highly disrupted ellipsoid zone (EZ) (p<0.001) and lower vision (p < 0.001). However, there was no difference in central foveal thickness (CFT) (p = 0.244) or subfoveal choroidal thickness (SFCT) (p=0.063). The CFT was defined as the distance from the inner surface of the inner limiting membrane to the inner surface of Bruch’s membrane at the fovea centre. The SFCT was defined as the distance from the inner surface of Bruch’s membrane to the innermost choroid-sclera interface. Chronic CSC had the significantly lowest VD both on the superficial and deep retina and the largest FAZ (0.39 ±0.13mm2) compared to acute CSC and controls (all p<0.05). There was no statistical difference between acute CSC and controls on VD or FAZ (both p>0.05). In chronic CSC, both the decreased VD on deep retina and expanded FAZ were correlated with a worse VA (both p<0.05). Limitations: The duration of the disease was defined from the time of the first presentation to the hospital. OCTA was carried out only in the affected eye.

Quantitative assessment of retinal capillary vessel density and foveal avascular zone area in central serous chorioretinopathy using OCTA.
Mao J, Lin J, Zhu L, et al. 
OPHTHALMOLOGICA
2020;243:370-8.