Journal Reviews

Mast cells in Graves’ ophthalmopathy

1 August 2016 | | Ophthalmology | Graves’ ophthalmopathy, Histamine, Histamine receptor type-1, Loratadine, Mast cell, NF-κB controlled cytokine, NF-κB inhibitor, Orbital fibroblast

Graves’ ophthalmopathy (GO) is a potentially sight-threatening ocular disease, occurring in patients with hyperthyroidism due to Graves’ disease. Also known as thyroid-associated ophthalmopathy, GO is characterised by orbital infiltration by immune cells including macrophages, T cells and plasma cells, which...