Investigating MOG-IgG as a cause for optic perineuritis

Optic perineuritis can be a manifestation of infectious and systemic inflammatory disorders, but in most cases is considered idiopathic. Diagnosis is established by magnetic resonance imaging (MRI) with the demonstration of optic nerve sheath enhancement with sparing of the optic...

Examination of optic disc drusen using computer-based fundus analysis

This case-control study analysed the optic disc angioarchitecture in optic disc drusen (ODD) using computer-based fundus examination. A group of ODD patients were compared to a group of healthy controls with normal optic discs. The cohort included 30 healthy volunteers...

A novel presentation of optic disc oedema with syphilis

Optic disc oedema (ODE) due to syphilis without visual compromise has been primarily attributed to papilloedema from raised intracranial pressure or optic perineuritis from optic nerve sheath inflammation. These terms were proposed before magnetic resonance imaging (MRI) was largely available....

Mechanism of colour vision involvement in multiple sclerosis

There is evidence to show that the optic nerve and retina are affected in multiple sclerosis (MS) even without any clinical evidence or history of optic neuritis (ON). MS without optic neuritis causes colour-vision deficit, however, the evidence for selective...

Using small amplitude saccades to assess saccadic velocity

Saccades are a key component in the assessment and diagnosis of neuro-ophthalmological disorders. Clinicians are typically taught to use large amplitude saccades (LAS) of at least 20 degrees to assess saccadic velocity. It has been suggested, however, that small amplitude...

Saccadic eye movements in young-onset Parkinson’s disease

The objective of this study was to understand control of saccadic eye movements in patients with young onset Parkinson’s disease (YOPD) where onset of disease symptoms appears early in life (<40 years of age). Functional magnetic resonance imaging (fMRI) was...

Long-term treatment of blepharospasm using Botulinum Toxin A

The authors report findings from a retrospective single-centre study which aimed to evaluate the efficacy and safety of long-term botulinum A toxin (BAT) treatment in patients with blepharospasm (BPS). Blepharospasm is described as one of the most frequent types of...

Using video-oculography to record monocular eye movements

The aim of this study was to examine the characteristics of monocular eye movements recorded using video-oculography (VOG). VOG monocular recording has become increasingly popular in comparison to electro-oculographic binocular recording, due to its simple technique. The authors evaluated the...

A case of ipsilateral fourth nerve paresis and Horner’s syndrome

The author presents a single case report of an exceptional association between fourth nerve palsy and ipsilateral Horner’s Syndrome. The case is presented alongside magnetic resonance images (MRI) which reveal a mass in the right cavernous sinus. The 54-year-old woman...

Benefit of selenium and vitamin D supplementation in thyroid eye disease

There is some limited evidence of as association between thyroid eye disease (TED) and nutritional deficiencies including selenium and vitamin D. Prior studies show that selenium can reduce TPO-antibody concentrations and improve hypothyroidism and post-partum thyroiditis. Limited evidence also shows...

Link between compression of anterior visual pathway structures and visual deficit

The compression of anterior visual pathway (AVP) structures can be observed on neuroimaging. It is not clear whether or not this compression results in damage to these structures. The authors present a single centre retrospective case record review over the...

Choroidal vascularity in NAION

The authors present a cross-sectional, non-interventional study of healthy volunteers and those with non-arteritic anterior ischaemic optic neuropathy (NAION) recruited over a six-month period at a single site. NAION is the most common cause of acute optic neuropathy over the...