Journal Reviews
Do patients with prolactinomas using dopamine agonist drugs have autonomic dysfunction?
This prospective study aimed to determine whether there is autonomic dysfunction in patients with prolactinomas using dopamine agonist (DA) drugs by measuring static and dynamic pupillary responses using an automatic pupillometric device.Included were 25 eyes from 25 patients who were...
Visual prognosis in Irish Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...
Transient thickening of the macular retinal nerve fibre layer in acute optic neuritis
Acute optic neuritis (ON) causes axonal degeneration, which can be quantified from the blood by neurofilament protein (Nf) levels. Within about three months, atrophy of the retinal nerve fibre layer (RNFL) follows. However, it remains challenging to explain why there...
Assaying acetylcholine receptor antibodies in the diagnosis of ocular myasthenia
Myasthenia gravis (MG) is an autoimmune disease that leads to impaired neuromuscular transmission. Solely ocular manifestations of MG (OMG) occur in 15-50% of cases, most frequently in the form of fluctuating ptosis and diplopia. Most cases of OMG convert later...
Prevalence of misdiagnosis of third nerve palsy by referring clinicians
The authors present a retrospective case review of new patient presentations to a neuro-ophthalmology clinic at two centres between 2014 and 2017. The electronic medical records were searched using the variety of terms for third nerve palsy. Referral for management...
New prognostic model for multiple sclerosis after optic neuritis presentation
The authors present a post-hoc analysis using the publicly available data set from the Optic Neuritis Treatment Trial. The Cox proportional hazards regression models were used to assess for associations between clinical and radiological variables and the development of clinical...
Test combination which could detect prodromal Alzheimer disease
The authors prospectively recruited a convenience sample of individuals aged over 65 and either with a diagnosis of mild cognitive impairment (MCI) due to Alzheimer disease or normal cognition. Other types of dementia and severe neurological conditions were excluded. All...
Care pathway to imaging delays for acute oculomotor nerve palsies
A retrospective chart review is presented with the aim of evaluating arterial imaging in cases of third nerve palsy. The study reviewed patients seen with a suspicion of or a final diagnosis of third nerve palsy over a seven-year eight-month...
Care journeys of patients with central retinal artery occlusion
The authors present a retrospective case note review of all adult patients referred for or diagnosed with central retinal artery occlusion (CRAO) to a single tertiary hospital over a 10½ year period. A total of 181 patients were included in...
Transient visual loss caused by crowded optic discs
The author presents four cases of transient visual loss (TVL) in young females (age range at presentation 14-22 years) with crowded optic discs. Patient demographics, investigations, medical and social histories are provided for all patients. A review of evidence for...
Assessment of slow and fast vergence in stroke survivors
The authors present the findings of a prospective cohort study. Three hundred and five stroke survivors were recruited consecutively. The following exclusion criteria were applied; aphasia, cognitive impairment, visual inattention, ocular motor nerve palsy and neuromuscular disease. Fifty age-matched controls...
Screening for visual processing deficits in dementia
The Queen Square Screening test for Visual Deficits (QS test) screens for changes in visual processing. It has never been formally validated as a single test. The test consists of a short booklet developed using remnant object and spatial perception...
