RTP801 as a neuroprotective and axon regenerative treatment

This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...

Amiodarone-associated optic neuropathy

This is a retrospective population-based cohort study to evaluate the risk of developing optic neuropathy from the use of amiodarone in Taiwan. Over a five-year period (2005-2009), there were 6175 amiodarone-treated patients with 24,700 patients taken as controls. After a...

A case report of bidirectional aberrant upward eye movement

The authors present a case report of a 14-year-old boy with left ptosis and strabismus since childhood. In primary position he had left hypotropia with ptosis. On elevation of the right eye, the left eye depresses and adducts. Conversely, on...

A novel computerised portable pupillometer detects and quantifies relative afferent pupillary defect

We have all had referrals from A&E telling us that a patient can’t see out of one eye. Sleepily we may ask “Is there an relative afferent pupillary defect (RAPD)?” to evaluate the seriousness of the presentation. The response is...

A rare case of ophthalmic complications following allergic fungal sinusitis

The authors present an unusual case report of a 32-year-old man with advanced allergic fungal sinusitis, presenting with severe bilateral visual loss and restricted ocular motility. On presentation he had an 18 month history of progressive nasal obstruction, as well...

Placement of an eyelid weight as an upper lid spacer for lagophthalmos

Upper lid loading with a weight is a well described procedure for the treatment of lagophthalmos and exposure keratopathy. The authors describe a modification of this procedure whereby the levator aponeurosis is recessed in combination with supratarsal weight implantation. The...

Positive diagnosis of acute posterior ischaemic optic nerve neuropathy

Posterior ischaemic optic neuropathy is a rare cause of visual loss believed to be due to infarction in the territory of the pial branches of the ophthalmic artery. There is an absence of clinical signs which means the diagnosis is...

Rituximab as an immunosuppression treatment for thyroid eye disease

Thyroid eye disease is traditionally treated with high dose glucocorticosteroids and surgical orbital decompression, where responses are often inadequate. This medical treatment is centred around symptom control and reduction of thyroid hormone synthesis, not immunosuppression. Rituximab is an anti-CD20 monoclonal...

Selection of visual field test for detection of pituitary disease

This prospective cross-sectional diagnostic accuracy study compared Octopus semi-automated kinetic perimetry (SKP) and Humphrey static automated central perimetry for detection of neurological visual field loss in patients with pituitary disease. Humphrey central 30-2 SITA threshold programme results were compared with...

Association between neuro-ophthalmology signs and chronic ataxia in children

Neuro-ophthalmological signs (N-OS) occur commonly in children with chronic ataxia. This study describes the N-OS and their frequencies, in general and by specific disease aetiology in paediatric patients with chronic ataxia. In total, 184 patients under the age of 17...

Visual outcomes, visual fields and optical coherence tomography in paediatric craniopharyngioma

This study reviews the visual outcomes of ten patients under the age of 18 years with craniopharyngioma. The paper also reviews the correlation between visual field (VF) testing and optical coherence tomography (OCT) examination and evaluates the role of OCT...

A case series of acquired esotropia in cerebellar disease

Acquired esotropia in cerebellar disease is well described but under-recognised. The pathogenesis of cerebellar esotropia is controversial. It is suggested it may be a result of disruption to central vestibular pathways. This article reports a case series of seven adults...