Journal Reviews
Comparison of bleb grading and IOPs
The purpose of this study was to compare a novel anterior segment optical coherence tomography (AS-OCT) bleb grading system with a clinical bleb grading system (Moorfields) and both with intraocular pressure (IOP) levels following trabeculectomy surgery. The authors developed a...
Optimising treatment with transscleral cyclophotocoagulation
This study compares the outcomes of transscleral diode laser cyclo-photo-coagulation with the treatment parameters used. This was a retrospective chart review of a random sample of diode laser procedures using the G-probe over 10 years for uncontrolled glaucoma. The main...
Four key questions and answers for glaucoma practitioners
In this discussion paper the authors pose four questions for the clinician diagnosing and monitoring glaucoma, and supply evidence-based answers. Worldwide, the most common functional test used to diagnose and monitor glaucoma is static automated perimetry, most typically with a...
Beware the disc in myopic patients
Glaucoma is a chronic and progressive optic neuropathy characterised by damage of retinal ganglion cells. Evaluation of structural damage of the optic nerve is important in glaucoma diagnosis. The ISNT rule states that the neuroretinal rim width is generally widest...
Transcriptomic analysis of ocular tissues
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...
One-year result of XEN45 implant for glaucoma: efficacy, safety, and postoperative management
The authors report a retrospective, non-randomised interventional case series of 39 patients who underwent a standalone XEN45 implantation. All 39 patients (female: male=1.2: 1) completed 12-month follow-up. Mean age was 70.1 years (range 32–92). Primary outcome measures were the intraocular...
Effect of intravenous mannitol in post vitrectomised eyes
The purpose of the study was to evaluate the effect of intravenous mannitol 20% on intraocular pressure in vitrectomised silicone-oil filled eyes. A prospective analysis of consecutive patients was undertaken with their fellow eyes taken as controls. Thirty-one patients were...
Uveitic glaucoma
The purpose of this retrospective study from two tertiary Institutions in Israel over a period of 13 years, is to present the long-term outcomes of uveitic glaucoma and to identify risk factors for progression. The study included 34 patients (53...
Long-term outcome of ALPI for plateau iris syndrome
The purpose of this study was to evaluate the long-term outcomes of plateau iris syndrome (PIS) patients treated with argon laser peripheral iridoplasty (ALPI) following YAG laser peripheral iridotomy (LPI). Typical ALPI settings were a spot size of 200 to...
Long-term specular microscopy following Nd: YAG iridotomy in chronic POAG
The aim of this study was to evaluate specular microscopy of chronic primary angle-closure glaucoma (CPACG) eyes at least one year after Nd:YAG iridotomy, and compare them with CPACG eyes without an iridotomy and age-matched, normal eyes. Nd:YAG laser causes...
Ologen Collagen Matrix to treat ocular hypotony after filtration glaucoma surgery
The authors report a retrospective, observational case series of a Japanese cohort. 12 consecutive implantations of ologen in nine eyes of nine subjects (five men, four women; mean age ±SD, 72.1±12.7 years) who underwent subconjunctival implantation of the device to...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
