Journal Reviews
Beware the disc in myopic patients
Glaucoma is a chronic and progressive optic neuropathy characterised by damage of retinal ganglion cells. Evaluation of structural damage of the optic nerve is important in glaucoma diagnosis. The ISNT rule states that the neuroretinal rim width is generally widest...
Transcriptomic analysis of ocular tissues
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...
One-year result of XEN45 implant for glaucoma: efficacy, safety, and postoperative management
The authors report a retrospective, non-randomised interventional case series of 39 patients who underwent a standalone XEN45 implantation. All 39 patients (female: male=1.2: 1) completed 12-month follow-up. Mean age was 70.1 years (range 32–92). Primary outcome measures were the intraocular...
Effect of intravenous mannitol in post vitrectomised eyes
The purpose of the study was to evaluate the effect of intravenous mannitol 20% on intraocular pressure in vitrectomised silicone-oil filled eyes. A prospective analysis of consecutive patients was undertaken with their fellow eyes taken as controls. Thirty-one patients were...
Uveitic glaucoma
The purpose of this retrospective study from two tertiary Institutions in Israel over a period of 13 years, is to present the long-term outcomes of uveitic glaucoma and to identify risk factors for progression. The study included 34 patients (53...
Long-term outcome of ALPI for plateau iris syndrome
The purpose of this study was to evaluate the long-term outcomes of plateau iris syndrome (PIS) patients treated with argon laser peripheral iridoplasty (ALPI) following YAG laser peripheral iridotomy (LPI). Typical ALPI settings were a spot size of 200 to...
Long-term specular microscopy following Nd: YAG iridotomy in chronic POAG
The aim of this study was to evaluate specular microscopy of chronic primary angle-closure glaucoma (CPACG) eyes at least one year after Nd:YAG iridotomy, and compare them with CPACG eyes without an iridotomy and age-matched, normal eyes. Nd:YAG laser causes...
Ologen Collagen Matrix to treat ocular hypotony after filtration glaucoma surgery
The authors report a retrospective, observational case series of a Japanese cohort. 12 consecutive implantations of ologen in nine eyes of nine subjects (five men, four women; mean age ±SD, 72.1±12.7 years) who underwent subconjunctival implantation of the device to...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
DIY IOP – does it work?
Measuring intraocular pressure (IOP) plays a major role in glaucoma care as IOP is a parameter, along with visual field progression and optic disc cupping used to assess treatment effect. While Goldmann tonometry (GAT) is the gold standard, it only...
Nerve head in healthy humans using OCT-angiography
Optical coherence tomography angiography (OCT-A) is a recent, dyeless, and noninvasive imaging technique for evaluating depth-resolved vascular status by capturing the dynamic motion of the erythrocytes. It provides the flow map of major vessels and capillary plexuses separately in different...
Effects of phacoemulsification on IOP and drug use in glaucoma
For patients with comorbid cataract and primary open-angle glaucoma (POAG), guidance is lacking as to whether cataract extraction and traditional filtering surgery should be performed as a staged or combined procedure. Achieving this guidance requires an evidence-based understanding of the...
