Graham Wallace

Birmingham and Midland Eye Centre, Birmingham, UK.

JOURNAL REVIEWED: Experimental Eye Research

Latest Contribution

MicroRNA inhibits corneal neovascularisation

1 August 2018 | | Cornea / External Eye Disease | Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2

MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

Corneal stroma modelling under hypoxic conditions

1 August 2018 | | Cornea / External Eye Disease | Confocal fluorescence microscopy, Cornea, Corneal organ culture, Extracellular matrix, Stroma

The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...

Transcriptomic analysis of ocular tissues

1 August 2018 | | Glaucoma | Ciliary body, Cornea, Gene expression, Glaucoma, RNA sequencing, Trabecular meshwork, Transcriptome

Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...