This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
With advancement in science and technology in the last decade, the role of biomaterials and regenerative medicines has become increasingly important in the management of various ocular disorders. This book highlights the role of biomaterials in the restoration of vision...
This small retrospective study used high resolution optical coherence tomography (OCT) Heidelberg Spectralis to identify features which could determine the underlying aetiology of peripheral corneal thinning. Ten patients were included; five with diagnoses of degenerative peripheral thinning; Terrien’s marginal degeneration...
Neurodegenerative diseases are characterised by the chronic and progressive loss of neurons, which in turn results in loss of cognitive and physical functions. The World Health Organization has estimated that the disability-adjusted life years lost from neurological disease was about...
Surgical treatment for recurrent exotropia (ET) predominantly depends on the primary surgery. Modification of surgical dose may be required in secondary procedures. The aim of this study was to compare surgical outcomes of modified and conventional secondary surgery using lateral...
Surgical treatment for recurrent exotropia (ET) predominantly depends on the primary surgery. Modification of surgical dose may be required in secondary procedures. The aim of this study was to compare surgical outcomes of modified and conventional secondary surgery using lateral...
Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping corneal degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males in their 40’s and is known by many other names such as...
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are based on facts and which are ‘fake news’. Headline: Patients blinded by stem cells! How safe are they really? Ever since the successful results following...
This is an interesting literature review that looks into the recent advances concerning the corneal molecular and cellular processes that are involved in the wound healing response after excimer laser surface ablation and LASIK surgery. It talks about the complex...
Age-related macular degeneration (AMD) is a multifactorial condition influenced by genetics and lifestyle factors (Table 1). This article outlines several recent advances in AMD genetics, as well as evolving therapeutic concepts and established practical measures for the treatment and /...
Multiple visual prosthetic projects and other vision regeneration initiatives being tested in preclinical and clinical development worldwide illustrate continuing progress and opportunities in addressing profound blindness from hereditary retinal diseases and other causes (Table 1). Three implantable bionic vision systems...
“Is it a fact – or have I dreamt it – that, by means of electricity, the world of matter has become a great nerve, vibrating thousands of miles in a breathless point of time?” – Nathaniel Hawthorne, The House...