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Long-term outcomes for hereditary retinoblastoma

Earlier diagnosis and more rigorous treatment regimens have contributed to better outcomes for patients with retinoblastoma. This study looked at 24 patients with hereditary bilateral retinoblastoma treated with systemic chemotherapy during a ten year period (2001-2011). The medical notes were...

MicroRNA inhibits corneal neovascularisation

MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

Ocular neuromyotonia features

The authors present eight cases of ocular neuromyotonia (ONM) with an overview of the pathophysiology, aetiology, clinical presentations and possible treatments. Diagnosis was made only after thorough and repeated orthoptic examinations and review of medication history. An overview of the...

Why is there subretinal fluid at the macula?

This is a review article looking at the differential diagnosis of subretinal fluid in the macula that could be diagnosed as central serous chorioretinopathy (CSCR). The authors have categorised them into 12 groups: neovascular diseases, vitelliform lesions, inflammatory diseases, ocular...

Orbital cavernous haemangiomas

This is a review of orbital cavernous haemangiomas (orbital cavernous venous malformations) managed over a 12-year period at a tertiary referral centre. Painless proptosis was the commonest presentation. One hundred and sixty-four patients (96 female and 68 male) underwent surgery...

Computer-assisted surgery in the orbit

In this paper the authors describe the growing use of computer-assisted surgery in ophthalmology. It is already described as a powerful adjunct in neurosurgery and sinus surgery and here they describe their experience of using it for the orbit; specifically...

Lacrimal drainage system malignancies

This retrospective case series looks at the rare cases of lacrimal drainage system malignancies. The authors have identified 14 patients in 24 years, at a tertiary referral centre in the Indian subcontinent. Many previous publications have found squamous cell carcinoma...

Prognosis prediction using clinical findings for fourth nerve palsies

The authors present a retrospective review of a cohort of patients diagnosed with fourth cranial nerve palsy with more than six months follow-up, over a 10-year period at a single centre. Thirty-five patients were included in the study, and spilt...

Longitudinal findings in children with neurofibromatosis type 1

This retrospective chart review evaluates the ophthalmologic findings of children with neurofibromatosis type 1 (NF1). Optic pathway gliomas (OPGs) are the most common tumours found in children with NF1. Findings are compared between eyes with and without optic pathway gliomas...

A review of orbital plasmacytomas

This is a multicentre review of 30 patients with orbital plasmacytomas. There were equal numbers of males and females, and the average age at diagnosis was 57 years. All patients were either already diagnosed with systemic multiple myeloma or it...

Management of diffuse OSSN with topical chemotherapy

Ocular surface squamous neoplasia (OSSN) can be localised to the conjunctiva or, less commonly, diffusely spread over the conjunctiva and cornea. Localised OSSN can be treated by surgical removal with adjuvant cryotherapy and chemotherapy with low rates of recurrence. Diffuse...