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IAC vs. IVC chemotherapy for RB
This a single centre retrospective review of consecutive patients between 1997 and 2014, of all sporadic unilateral retinoblastoma (RB) group D cases, treated with combined intravenous chemotherapy (IVC) and focal treatments (1997- 2008), or intra-arterial chemotherapy (IAC) treatment (2008 to...
A phase 3 randomised trial of nicotinamide for skin cancer chemoprevention
To B3, or not to B3? That was the question asked in this controlled trial in which the authors were able to show that oral nicotinamide (vitamin B3) is able to reduce further skin cancer development in high risk patients....
Management of congenital NLD obstruction
The authors evaluated changes in management of congenital nasolacrimal duct obstruction (CNLDO) by surveying 1495 Association for Paediatric Ophthalmology & Strabismus (AAPOS) members. The survey consisted of 21 multiple choice questions with anonymised return. Responses were received from 127 members...
Are single IOP measurements adequate for estimating the effect of IOP lowering interventions?
The World Glaucoma Association recommends that, to assess the effect on intraocular pressure (IOP) of medication or surgery, the mean of multiple measurements of postoperative IOP is a better reflection of IOP than a single measurement of postoperative IOP. The...
Outcomes and complications of supramaximal levator resection
This is a report of 35 children with unilateral congenital ptosis who underwent a supramaximal levator resection, involving extensive dissection of levator including cutting Whitnall’s ligament. The average preoperative margin reflex distance to the upper lid (MRD1) was 0.5mm, and...
An educational intervention to improve adherence to high-dosage patching regimen for amblyopia
This is a randomised trial of patients recruited between the periods of March 2006 and March 2008 from ophthalmology clinics in the Leicestershire area. A total of 62 children with newly diagnosed amblyopia were allocated randomly into two treatment arms...
Blinking and driving
Spontaneous blinking is dependent on cognitive processes and is regulated by a central pacemaker that is highly sensitive to the attention demands and cognitive workload of the visual task in hand. There is evidence of a variability in the frequency...
Should intravitreal steroids be used in the initial treatment of post-op endophthalmitis?
Endophthalmitis following cataract surgery is one of the most feared complications, and can have significant impact on the visual outcomes of patients. The role of steroids in the management of endopthalmitis is controversial. The aim of this paper was to...
PRN Ranibizumab verses continuous aflibercept in UK clinical practice
This was a multicentre (21 UK hospitals), national EMR study on treatment naïve nAMD eyes, undergoing predominantly as needed (PRN) Ranibizumab or continuous (fixed or treat and extend - (F/TE)) Aflibercept (Af). The primary outcome was change in vision at...
Expert vs. non expert grading of ROP from digital video images
The primary purpose of this study was to determine whether digital video images of the retina obtained using an indirect ophthalmoscope imaging system could be accurately graded for zone and stage of retinopathy of prematurity (ROP) and the presence of...
Mid-term evaluation of the new Glaukos iStent
This is a prospective non-randomised interventional study to assess the efficacy and safety of the Glaukos GTS-400 iStent combined with cataract surgery. The patients enrolled in the study had cataract and primary open angle glaucoma, pseudoexfoliation glaucoma or ocular hypertension....
