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Clinical predictors of proliferative sickle cell retinopathy
Sickle Cell Disease (SCD) is an inherited disorder resulting in production of Haemoglobin S (HbS), which aggregates in conditions of hypoxia, acidosis or hyperosmolarity. This leads to vascular stasis, thrombosis and ischaemia. The authors present a cross-sectional study (45 consecutive...
MPH treatment effect in ADHD on choroidal vascular index
In this study the authors aimed to investigate the choroidal vascular index (CVI) in treatment-free children with ADHD, children regularly taking methylphenidate (MPH) and healthy controls. This was a prospective cross-sectional study of 52 patients with newly diagnosed ADHD, 46...
PAX6 methylation and myopia
The authors present a case control study of 41 adolescents (age 12–14) with myopia and 39 age- and sex-matched non-myopic controls. The myopic patients were sub-divided into mild, moderate and severe myopia subgroups. DNA was extracted from peripheral blood samples...
Macular choroidal changes after inferior oblique muscle surgery
This study was undertaken to investigate the retinal neurovasculature, choroidal thickness and choroidal vascular index (CVI) changes at the macula at one week, one- and three-month intervals post inferior oblique muscle myectomy. The hypothesis was that, given the close proximity...
Use of immunomodulatory treatment for non-infectious uveitis: an International
Two-hundred-and-twenty-one group members from 53 countries completed a questionnaire on their indications, investigations and use of conventional and biologics and follow-up of treated patients. Main indications to start systemic immunomodulatory drugs were: uveitis not controlled by oral prednisolone (94.1%), specific...
Mydrin-P microdrops vs mydrin-P standard drops for ROP examination
This was a non-inferiority prospective randomised controlled trial to compare efficacy and safety of microdrops over standard dose mydrin-P in retinopathy of prematurity (ROP) screening, and to determine optimal time for eye examination after administration of drops. The trial included...
Genetic cause for idiopathic foveal hypoplasia
The authors present a small cohort study of 19 patients with idiopathic foveal hypoplasia diagnosed based on optical coherence tomography (OCT) features. Peripheral blood samples from all 19 patients underwent next-generation sequencing and 33 genes known to be involved in...Moorfields surgeons save the sight of 24 wounded Bangladeshi students
Moorfields Eye Hospital consultant ophthalmologists Mahi Muqit and Niaz Islam were invited to Dhaka by Bangladesh’s interim government to help 120 patients with bullet wounds to their eyes. Their injuries were a result of their involvement in protests against the...Reflections on deployment to ICU
Being unexpectedly uprooted from ophthalmology to ICU during the coronavirus pandemic was certainly a challenge, not just clinically, but emotionally and personally. However, it is only through adversary that we learn to appreciate what we have, and there are definitely...Demodex blepharitis: A transatlantic comparison of treatments available in the UK and US
Demodex blepharitis is widely recognised among eyecare professionals as an important cause of chronic lid margin inflammation, dry eye and ocular surface diseases. The characteristic feature for diagnosis is the presence of waxy deposit at the lash bases on slit...
