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New mouse model of diabetes mellitus
Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...
PRN Ranibizumab verses continuous aflibercept in UK clinical practice
This was a multicentre (21 UK hospitals), national EMR study on treatment naïve nAMD eyes, undergoing predominantly as needed (PRN) Ranibizumab or continuous (fixed or treat and extend - (F/TE)) Aflibercept (Af). The primary outcome was change in vision at...
Temporal versus nasal clear corneal incisions
This is a prospective randomised study of 100 patients’ left eye having undergone phacoemulsification either by a 2.4mm nasal clear corneal incision (CCI) group or temporal CCI group. The corneal astigmatic changes were compared between groups by power vector analysis,...
Does amniotic membrane transplant improve outcomes in chemical injuries?
This single centre, randomised, parallel-controlled clinical trial compared the outcomes of patients with Roper-Hall grade IV ocular chemical injury that had conventional treatment vs. combined medical treatment and amniotic membrane transplantation (AMT). They followed up 60 patients between August 2006...
Effect of cataract surgery on inflammation control and vision in uveitis patients
This retrospective longitudinal study from Moorfields, London, UK compared uveitis recurrence rates and vision loss in 309 eyes of uveitis patients post cataract surgery to 300 control uveitis patients. Cataract is a common complication associated with uveitis and leads to...
Comparison between findings in OCTA and FA in patients with diabetic retinopathy
In this study the authors present a prospective cross-sectional comparative study of typical findings of diabetic retinopathy to analyse the agreement between the image modalities of optical coherence tomography angiography (OCTA) and fluorescein angiography (FA). Fifty-three eyes of 42 patients...
Silicone oil in rhegmatogenous retinal detachment
Silicone oil (SO), used in complicated retinal detachments, is associated with complications such as cataract, increased intraocular pressure (IOP), keratopathy, cystoid macular oedema (CMO), epiretinal membrane (ERM) and loss of vision. Emulsification of oil can also lead to migration of...
Treat-and-extend regimen in treatment of patients with type 3 neovascularisation
Type 3 neovascularisation, also known as retinal angiomatous proliferation is a distinct subtype of neovascular AMD characterised by intraretinal neovascularisation. This retrospective study included 17 eyes diagnosed with type 3 neovascularisation who were changed from pro-re-nata (PRN) based treatment regime...
Oculofacial plastic surgery – is antibiotic prophylaxis required?
This is a randomised, controlled, unmasked clinical trial evaluating whether topical antibiotic prophylaxis reduces the rate of infection after oculofacial plastic surgery compared to a non-antibiotic ointment. A total of 401 participants over the age of 18 were recruited, with...
Anterior ischaemic optic neuropathy post cataract surgery
This retrospective population-based cohort study assessed whether there was an increased incidence of anterior ischaemic optic neuropathy (AION) post cataract surgery compared to patients that had not had cataract surgery. They reviewed the notes of all patients diagnosed with AION...
Correlation between aqueous flare and macular microvascular status in diabetes mellitus
The authors report a cross-sectional study which was conducted to investigate the correlation between aqueous flare and macular microvascular status, assessed by optic coherence tomography angiography (OCTA) in diabetes mellitus. Fifty-two diabetic patients with non-proliferative retinopathy, 44 diabetic patients without...
