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PD-1 and PD-L1 in exenteration specimens
This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...
Conj reconstruction with amniotic membrane
This study reports the use of amniotic membrane in patients with restrictive strabismus or conjunctiva problems during or following complex eye muscle surgery. Ambio 5 was used for replacement of conjunctiva in this retrospective study of 32 cases aged one...
Proof of concept for using aqueous humour to detect retinoblastoma variant
A proof of concept study is presented with the aim of assessing the feasibility of using aqueous humour surrogate marker for tumour tissue for identifying retinoblastoma RB1 variant. Three children undergoing enucleation for retinoblastoma were recruited from a single centre....
Effect of phacoemulsification on trabeculectomy function
Previous studies have reported cataract surgery post trabeculectomy to be detrimental to IOP control. Conversely, other studies have reported phacoemulsification performed before trabeculectomy as a factor for bleb failure. The objective of this retrospective case control study was to evaluate...
Visual impairment in patients with glaucoma
This retrospective observational study assessed the prevalence of end-of-life visual impairment in patients with glaucoma. A total of 122 deceased patients followed for glaucoma were included and data was collected from patient notes. Sixty-one patients had open-angle glaucoma and 61...
A case report showing the natural history of papilloedema
The case report describes a 54-year-old woman who developed increased intracranial hypertension due to chronic dural venous sinus thrombosis in the absence of any significant comorbidity. In the years preceding diagnosis, the patient underwent routine diabetic retinopathy screening; however, gradual...
Idiopathic orbital pseudotumor as first sign of systemic inflammatory disease
The authors describe four children in whom idiopathic orbital pseudotumor (IOP) was the initial solitary finding with systemic inflammatory disease developing later. Four children were seen over a five-year period. Mean age was 9.75 years (2-14). Three were white and...Advances in the understanding, diagnostic and treatment of keratoconus
*Joint first authors Keratoconus is a bilateral and asymmetric eye condition in which the cornea’s structure is affected and thinned, causing a cone-shaped bulge to develop. This results in progressive loss of vision and impairs the ability of the eye...Spotlight: The Community Eye Health Journal
In many low-income settings, where vision loss is greatest, eyecare is hampered by shortages in trained health workers. In sub-Saharan Africa, there are fewer than five ophthalmologists per million population, compared to over 70 per million in high-income countries. Eyecare...The role of injection assistant devices in establishing a nurse-led AMD service
The author shares his experience of setting up a nurse-led service to deliver anti-VEGF intravitreal injections and how injection assistant devices supported training. Age-related macular degeneration (AMD) has become a leading cause of irreversible blindness [1]. It is estimated that...
