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Guide to Gaining Approval for a Clinical Study
This article focuses on gaining approval for clinical research involving NHS patients, although the principles can be applied to other types of research. The intention is to give an overview of the requirements for setting up a research study, but...
DMEK versus DSAEK
This systematic review and meta-analysis reviewed published evidence comparing two endothelial corneal transplants techniques; Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSEAK). DMEK involves transplanting Descemet membrane with endothelial cells without any overlying stroma. In DSAEK...
Steroid implants in the treatment of post-epiretinal membrane peel macular oedema
This is a retrospective review of 39 eyes of 37 patients treated with Ozurdex® (intravitreal dexamethasone implant) for persistent post-operative cystoid macular oedema (CMO) following vitrectomy and idiopathic epiretinal membrane (ERM) peeling. The 0.7mg implant was injected in each eye...
What about the children? Cornea cross-linking for children with keratoconus
Keratoconus can behave more aggressively in paediatric than in adult patients. Collagen cross-linking has been shown to slow the progression of keratoconus in adults. This systematic review determined the effectiveness of corneal collagen cross-linking (CXL) in children. For this study,...
Retinotopic fMRI reveals visual dysfunction and functional reorganisation in the visual cortex of glaucoma patients
This study investigated the retinotopic functional representation in the visual cortex of mild to moderate primary open-angle glaucoma (POAG) participants and age-matched normal volunteers, using wide-view visual presentation, high-resolution retinotopic stimuli, and high-resolution blood oxygenation level dependent (BOLD) functional magnetic...
Finasteride and central serous chorioretinopathy
The pathophysiology of central serous chorioretinopathy (CSC) is complex and has not been fully elucidated. Suggested theories include hyperpermeability and increased hydrostatic pressure in the choroidal vasculature, which creates RPE detachments overwhelming the RPE barrier function, leading to accumulation of...
Preoperative RPE alterations in macular holes
This retrospective interventional case series from Japan assessed whether preoperative alterations of the retinal pigment epithelial (RPE) in idiopathic macular holes correlated with postoperative functional and morphological changes in the macula. Fifty-nine eyes had preoperative Spectralis OCT using the ‘detailed’...
Macular hole postop positioning
The purpose of this study was to determine whether the full thickness macular hole (FTMH) closure rate with nonsupine positioning (NSP) is noninferior to the high closure rate achievable with face down positioning (FDP). All patients were pseudophakic pre macular...
Retinal structural features of CMV retinitis
Confocal adaptive optics (AO) technology has enabled cellular level retinal imaging, including imaging of photoreceptors and blood flow. Adaptive optics scanning laser ophthalmoscopy (AOSLO) is a technology that provides high resolution and high contrast retinal images by correcting ocular aberrations....
Visual recovery following Ex-Press vs. trab
The authors describe a prospective randomised study of 64 POAG subjects with controlled IOPs comparing visual acuity data in patients randomised to either Ex-Press model P50 or trabeculectomy. Visual acuities were recorded at baseline, day one, weeks one and two...
Comparison of ganglion cell thinning in glaucoma vs. macular hole repair
This prospective study compared the changes in the photopic negative response of the focal macular electroretinogram (fmERG) caused by retinal ganglion cell complex (GCC) thinning at the macula between patients with open angle glaucoma (OAG) and 12 months after successful...
