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MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Overview of traumatic optic neuropathy
The authors present the clinical features and role of various treatment modalities on the final vision outcome in traumatic optic neuropathy (TON). They retrospectively reviewed the records of patients with a diagnosis of TON over a four year period in...
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
A case report of cavernous sinus syndrome following dental procedure
This case report describes a patient presenting with painful diplopia as a consequence of root canal dental treatment. Following root canal treatment a non-resolving tooth pain led to a decision to extract the tooth, leading to onset of severe periorbital...
HtrA1 enhances cell senescence
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...
CAT-QoL questionnaire
The purpose of this study was to use Rasch analysis to inform the refinement of the CAT-QoL amblyopia treatment questionnaire. Of the 342 subjects that were recruited across nine centres, 315 had sufficient clinical data for analysis with RUMM software....
Use of group consultations in the management of idiopathic intracranial hypertension
The incidence of idiopathic intracranial hypertension (IIH) has risen by >100% between 2002 and 2016 in the UK, in association with rising obesity rates. This increasing incidence has inevitably led to increased pressures on service capacity. Evidence for other conditions...
Factors associated with inferior oblique transposition surgery and occurrence of anti-elevation syndrome
The purpose of this study was to correlate the frequency of anti-elevation syndrome (AES) with the magnitude of the anterior transposition of the inferior oblique. This was a retrospective study of 312 eyes of 170 patients. Mean age at surgery...RCS England response to latest NHS waiting times data
The latest NHS consultant-led referral-to-treatment data shows that the total waiting list increased by 6,002 in October 2025, reaching 7.3 million. Analysis reveals the percentage of patients who began treatment within 18 weeks slightly decreased to 61.7%, indicating minimal progress...Codifying ‘care’ and ‘cure’ behaviours of artificial intelligence systems: now out in Nature Medicine
A new publication in Nature Medicine discusses 'Building a code of conduct for AI-driven clinical consultations' The diversity of AI applications in medicine is growing at an accelerating rate, with that trend set to continue as technology develops. This diversity...
