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1809 results found

Long-term effect of gene therapy on Leber’s congenital amaurosis

After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...

Clinicopathologic factors and survival in patients with sebaceous carcinoma of eyelid

This is a population-based analysis performed to evaluate the prognostic factors and survival of patients with sebaceous carcinoma of the eyelid. Patients with eyelid sebaceous carcinoma from 1973-2013 were identified from the Surveillance, Epidemiology and End Results (SEER) database and...

Differentiating orbital tumours on MRI

This is a literature review examining the ability of specific MRI modalities to differentiate between benign and malignant tumours of the orbit. The authors identified 29 articles reporting diffusion weighted image (DWI) values and corresponding apparent diffusion coefficients (ADC) for...

Customised orbital implants

This is a literature review of the outcomes of orbital fracture repairs using custom-made orbital implants. Customised implants were manufactured in one of three ways, all using a 3D printer; manual moulding of an implant based on a 3D-printed model...

How reliable is the postoperative diplopia test and can it predict postoperative outcomes?

A two-phase process evaluating the postoperative diplopia test is presented. A standardised operating procedure was used for conducting all postoperative diplopia tests for this study which is described in the paper. Phase one focused on reliability, test-retest and interobserver. Adults...

Higher risk of poor functional outcome in the presence of visual deficits post-stroke

The authors present a retrospective case review with the aim of reporting the disability outcomes of individuals 90-days post stroke with and without visual deficits. The Houston Methodist Hospital Outcomes-based Prospective Endpoints in Stroke (HOPES) Registry was used as the...

How common is ocular trauma in children and what are the clinical features?

The authors present a multicenter retrospective case review with the aim of reporting the incidence and characteristics of paediatric ocular trauma. Records for individuals aged 18 and under with a diagnosis of globe, orbit or adnexal injury over a 10-year...

Clinician predictions and the perspectives of parents prior to strabismus surgery compared

The aim of this study was to assess the perspectives and concerns of parents in relation to exotropia surgery in comparison to how clinicians predicted parents would respond. Parents of children with intermittent exotropia who underwent surgery over a nine-month...

Photophobia associated with migraine: Investigating associations with productivity

The aim of this study was to investigate an association between severe photophobia linked to migraine and reduced work productivity. Cases were extracted from the American Registry for Migraine Research (ARMR) with the following criteria: diagnosed with migraine, data available...

Retinoblastoma management update (part 2): treatment, screening and surveillance, long-term follow-up and new developments

Retinoblastoma treatment requires significant multidisciplinary input, but early detection through raising awareness remains key to improving outcomes. In the second article of a two-part series, Manoj Parulekar discusses retinoblastoma management, screening and research. This article has been published in two...

Post-stroke visual impairment: how big is the problem, how do we identify it, what we can do about it, and why does it matter?

In the UK, 100,000 new strokes occur each year, with 1.3 million stroke survivors [1]. This article will focus on post-stroke visual impairment, discussing topics of how common it is, how it can be detected, possible management options and how...

COVID-19 and the eye: a review of ocular involvement and protective strategies

A lot of attention has been placed on the use of face coverings to limit COVID-19 transmission, but there has been less focus on ocular involvement and ocular protection strategies. The author reviews the literature and discusses possible solutions. The...