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PD-1 and PD-L1 in exenteration specimens
This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...
Retrobulbar amphotericin B for rhino-orbital-cerebral mucormycosis
Rhino-orbital-cerebral mucormycosis (ROCM) is a rare and often fatal infection usually occurring in immunocompromised patients from diseases such as diabetes, haematological malignancy and solid organ transplantation. Current standards of care include systemic antifungal therapy and debridement, including exenteration. This study...
Changes in parafoveal retinal thickness after bariatric surgery in type 2 diabetics
Bariatric surgery induces an instant normalisation of blood glucose in as many as 80% of patients with type 2 diabetes. It has been previously reported that diabetic retinopathy (DR) is stable within one year after bariatric surgery. In this study,...
Handheld OCT in children with Down’s syndrome
This article investigated the use of handheld optical coherence tomography (OCT) in children with Down’s syndrome. Fourteen children were recruited to the study with a mean age of 6 years and 10 months with 57% male. All patients were dilated....The International Centre for Eye Health: weaving the global threads together
The VISION 2020 LINKS & Networks Programme has been writing regular articles in Eye News about its capacity-strengthening activities in low- and middle-income countries (LMICs) for more than a decade. This, the first International Issue, is a landmark for Eye...Virtual reality for the ophthalmic trainee
If you believe the tech blogs 2015 is the year of virtual reality. Industry experts believe this will be due to the potential commercial release of the poster boy of this new revolution, the Oculus Rift. This is a headset...
Silicone band loop myopexy in the treatment of myopic strabismus fixus
This is a retrospective case series of chart review of patients who had silicone band loop myopexy between January 2008 to December 2012 for myopic strabismus fixus (MSF) at a tertiary eye centre in India. A minimum period of two...Supranuclear ocular motility disorders
Figure 1: Bilateral INO Introduction Complex ocular motility disorders are a diagnostic challenge. These patients come with very complex ocular motility presentations and require a careful and detailed assessment in order to find the correct diagnosis and arrange appropriate investigations....Navigating the retina: the nitty-gritty of slit-lamp fundus examination
The slit-lamp fundus examination can be a difficult and disorientating task for beginners due to the retina being viewed in a non-anatomical orientation, the small area of retina illuminated, and the counterintuitive technique of the examination. This article provides a...Artificial intelligence and oculomics: Improving global health
The application of artificial intelligence (AI), and in particular deep learning, to high-resolution ocular imaging has led to many new discoveries, enabling the prediction of multiple different systemic diseases from ocular biomarkers. This emerging field is known as ‘oculomics’ [1]....Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...
