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IgG4 related orbital disease
This retrospective study was done to determine the prevalence of IgG4 related orbital disease (IgG4ROD) in patients who previously had biopsies for suspected idiopathic orbital inflammatory disease (IOID) and / or orbital lymphoproliferative disease (OLD). The charts and slides of...
Complement Factor H and Factor H-Like protein are expressed in human RPE cells
The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...
A rare case of oculomotor nerve palsy from presumed cavernous angioma
Cavernous angiomas of the cranial nerves are extremely rare, and those of the oculomotor (third) nerve are rarer still. The authors present a single case study of presumed cavernous angioma involving the subarachnoid portion of the left third nerve, which...
Differentiating orbital cellulitis from non-specific orbital inflammation
This is a retrospective study looking at whether common laboratory investigations can help differentiate between orbital cellulitis (OC) and non-specific orbital inflammation (NSOI). NSOI is a diagnosis of exclusion following negative investigations for systemic diseases such as IgG4-related disease, granulomatosis...
Comparison between findings in ‘active’ or ‘healed’ giant cell arteritis
Giant cell arteritis (GCA) is the most common systemic vasculitis in older people and can cause devastating sight loss if untreated. Temporal artery biopsy is often relied upon for diagnosis by ophthalmologists, with a positive biopsy result indicating whether the...A European ophthalmology perspective
Europe: from the Greek eurus: broad, wide, and ops: eye, face, sight. Thus Europe = the far-sighted (lady). For my first contribution to this column – as the successor of Jonathan Park, whose witty observations and entertaining style many of...
Teprotumumab for chronic TED
This retrospective case series looks at the use of teprotumumab in nine patients with thyroid eye disease (TED) of clinical activity score ≤one and >nine months duration, in an American cohort. Current European guidelines have suggested the use of teprotumumab...
Lucentis for pseudophakic CMO
Pseudophakic cystoid macular oedema (CMO) develops angiographically in up to 20-30% after uneventful phacoemulsification. This study aimed to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic CMO after cataract surgery. Seven eyes were included in...Pigmented paravenous retinochoroidal atrophy
Presentation A 46-year-old Caucasian female was referred to the eye clinic by her local optician following a routine sight test. She was noted to have pigmentary retinal changes in both eyes but was asymptomatic with no visual complaints. At presentation...Issues with standard practice: Luer lock syringes in cataract surgery
For a few years, we have worked together with the practice variance surveys to tease out differences in the way we work and to discuss issues that arise. I hope that we have learnt some lessons and reflected on what...Developments in oculoplastic surgery
A study of NHS practice demonstrated significant patient-reported quality-of-life improvements from commonly performed oculoplastic operations: entropion repair, ectropion repair, ptosis repair and dacrocystorhinostomy (DCR) [1]. In recent years, surgical and non-surgical approaches to functional and aesthetic oculoplastic surgery have advanced...
