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Limbal melanocytes and the stem cell niche

The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...

Statins inhibit TGFβ2 mediated fibrotic response in astrocytes

Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...

Could medical cannabis be used to successfully treat blepharospam?

This study observed the effect of medical cannabis in benign essential blepharospasm (BEB), in addition to standard botulinum toxin treatment. The study comprised of a retrospective chart review on eligible patients and included information on patient demographics, responses, cannabis history...

Hemianopia or visuospatial neglect: differences in information processing

It is widely reported that visuospatial neglect and hemianopia may be superimposed, and disentangling the two conditions can be pose difficulties for clinicians. The authors of this paper explored the differences in implicit information processing which is effective in patients...

Treatment for post stroke visual impairment – clinical practice versus literature evidence

The aim of this paper is to compare the treatments reported in a large scale stroke study (Vision in stroke (VIS) Study) against the treatments identified in a full systematic literature review. The purpose was to identify which treatment /...

IOP measures after intraocular chemotherapy

This study aimed to describe the relationship between intravitreal chemotherapy and IOP in children with retinoblastoma and identify risk factors for pronounced elevations. This was a retrospective study of ten cases (ten eyes) with 17 encounters overall. Mean age was...

Somatostatin protects retinal pericytes

Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...

γδ T cell depletion does not affect fungal keratitis

Fungal keratitis (FK) is a blinding condition prevalent in agricultural areas of countries such as India and China. The fungus enters the cornea and induces an inflammatory response which leads to tissue damage. Neutrophils are the earliest infiltrating immune cells...

Topical atorvastatin for dry eye and blepharitis

Dry eye is a very common problem with 20% of the population affected and is frequently associated with blepharitis (DEB), which has an over prevalence of about 40%. The aim of this study was to evaluate a topical atorvastatin formulation...

Cytotoxic effect of voriconazole on human corneal epithelial cells

Voriconazole is a second-generation synthetic derivative of fluconazole with broadened antifungal spectrum. It is becoming the drug of choice for fungal keratitis. Voriconazole eye drops are not available commercially, thus have to be prepared by diluting the intravenous formulation containing...

Air toxicity on retinal pigment epithelium

This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...

Influence of overall intraocular lens diameter on rotational stability

It has been shown that approximately one in three patients undergoing cataract surgery have >1.0D corneal astigmatism and managing this during surgery is important to achieve good refractive outcomes. One of the widely used ways of reducing preoperative astigmatism during...