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Inhibiting high-risk corneal allografts
The cornea is an immune privileged site and as such corneal transplants are very successful. However, in situations where this privilege is lost the failure rises substantially. To combat rejection inhibition of the immune responses depends on steroids and other...
New mouse model of diabetes mellitus
Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...
Macular atrophy with aflibercept
The authors of this paper set out to investigate the prevalence of macular atrophy in treatment-naive patients with neovascular AMD undergoing aflibercept monotherapy (three monthly loading injections followed by subsequent treatment every two months). Case notes over a three year...
OCTA in angioid streaks
This paper reports on the optical coherence tomography angiography (OCTA) features of choroidal neovascularisation (CNV) secondary to angioid streaks and the ability to predict CNV activity. A total of 38 eyes of 19 patients were included in the study. Thirty...
Retinal ischaemia on OCTA and diabetic retinopathy grade
The authors quite rightly point out that quantification of retinal ischaemia has the potential to serve as a biomarker for diabetic retinopathy disease progression. They set out to investigate the relationship between area of ischaemia on a swept source OCTA...
Electrocautery and implantable cardiac devices
This is a literature review of the risks associated with bipolar and monopolar electrocautery in patients with a permanent pacemaker (PPM) or implantable cardioverter defibrillator (ICD). The authors found 12 publications which met their inclusion criteria, but within these there...
How reliable is the postoperative diplopia test and can it predict postoperative outcomes?
A two-phase process evaluating the postoperative diplopia test is presented. A standardised operating procedure was used for conducting all postoperative diplopia tests for this study which is described in the paper. Phase one focused on reliability, test-retest and interobserver. Adults...
Normative data using a virtual reality game-based visual field test
The authors present a prospective cross-sectional study involving healthy children to assess the use of a virtual reality game-based perimetry assessment. A single eye centre recruited through paediatric optometry and ophthalmology clinics over a 12-month period. Children aged <18 years...
