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Intensive diabetes therapy and ocular surgery in type 1 diabetes
The Diabetes Control and Complications Trial (DCCT) ran between 1983 and 1993 and showed that intensive glycaemic control was beneficial in reducing diabetic retinopathy in type 1 patients. There was a 76% reduction in onset of retinopathy and a 52%...
Long-term effect of gene therapy on Leber’s congenital amaurosis
After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...
PI drops and respiratory change during surgery
Five percent povidone-iodine (PI) topical application to the eye has been observed to cause apnoea under general anaesthetic (GAS). The authors designed a randomised single-blinded controlled trial to evaluate changes in respiration caused by PI eye drops. They recruited 100...
Can coenzyme Q10 have a protective role in ethambutol-induced retinal ganglion cell toxicity
Tuberculosis (TB) is one of the most prevalent infectious diseases, especially in developing or low- income countries. Ethambutol is a widely used drug to treat TB. Ethambutol can cause visual disturbance including ethambutol toxic optic neuropathy (ETON). ETON is one...
Randomised controlled trial of CAM training vs occlusion for amblyopia therapy
The main aim of this study was to compare the effect of Cambridge vision stimulator (CAM) therapy with passive occlusion in the management of unilateral amblyopia. This was an randomised control trial (RCT) with two groups; group 1 with CAM...
Dexmedetomidine vs remifentanil for reduction of postoperative agitation
Postoperative agitation is a common anaesthetic complication in children with a significant impact to care and outcomes. The authors studied preschool children to compare the effect of intravenous administration of dexmedetomidine and remifentanil on postoperative agitation following strabismus surgery under...Effective treatment for rare sight-threatening infection
A drug candidate, based on pioneering UCL and Moorfields Eye Hospital research and currently under development by SIFI S.p.A., has been found to be highly effective in treating a rare sight-threatening eye infection in a new international clinical trial.Pioneering eye device restores reading vision to blind eyes
A pivotal European clinical trial of a new electronic eye implant has seen remarkable results. The study, published in the New England Journal of Medicine, showed 84% of participants were able to read letters, numbers and words using prosthetic vision...Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease
Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...Ocular manifestations of multiple sclerosis: an overview
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS), in which there is dissemination of lesions in time (two or more clinical events) and space (multiple lesions seen on brain and spinal imaging). The pathophysiology...Moorfields Lacrimal assessment for nursing & allied professionals study day
This course will educate nurses and allied health professionals on lacrimal examination and investigation. A hands on teaching approach ensures that delegates are able to demonstrate safe and effective lacrimal technique, whilst the patient's perspective as a service user remains...
