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Oxford Rheumatology Library: Sjögren’s Syndrome

This is a handy little book which covers everything you need to do know (and then some) about Sjögren’s syndrome. It is split into nine sections: Epidemiology, genetics and disease burden Diagnosis and clinical assessment Oral features Ocular features Fatigue,...

Topical insulin for neurotrophic ulcers

This retrospective case series described the use of topical insulin drops as an aid in treatment of refractory neurotrophic corneal ulceration in six patients. Insulin drops were prepared under sterile conditions from standard insulin preparations mixed with artificial tears containing...

Treatment options for septic cavernous sinus thrombosis

Septic cavernous sinus thrombosis is a rare but serious complication of infection of the cavernous sinuses. Potential therapies include antibiotics, corticosteroids and anticoagulation, as well as surgical intervention for source control of the infection. The authors report that there is...

Combined ranibizumab and ablative therapy for Coat’s disease

The aim of this study was to observe the efficacy of intravitreal ranibizumab (IVR) combined with laser photocoagulation or cryotherapy, for Coats’ disease. Patients younger than 16 years of age who were diagnosed with Coats’ disease were included in this...

Treatment for post stroke visual impairment – clinical practice versus literature evidence

The aim of this paper is to compare the treatments reported in a large scale stroke study (Vision in stroke (VIS) Study) against the treatments identified in a full systematic literature review. The purpose was to identify which treatment /...

Neurotrophic keratitis

The authors present an overview of the aetiology, diagnosis, current and future management options of neurotrophic keratitis. This is a degenerative corneal disease that occurs following the compromise of trigeminal innervation, leading to hypoesthesia and / or anaesthesia. The aetiology...

The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy

The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...

Low dose steroids with elevated IgG4 levels

This is a retrospective case series review of 28 biopsy-proven IgG4-related ophthalmic disease (ROD) patients treated between March 2010 – January 2017 from Seoul, Korea. The mean follow-up period was 27.3 months. Lacrimal glands were involved in all patients and...