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Retinal changes in Leber hereditary optic neuropathy

The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time, in patients with Leber’s hereditary optic neuropathy (LHON). For this study, 21 patients...

Anterior ischaemic optic neuropathy post cataract surgery

This retrospective population-based cohort study assessed whether there was an increased incidence of anterior ischaemic optic neuropathy (AION) post cataract surgery compared to patients that had not had cataract surgery. They reviewed the notes of all patients diagnosed with AION...

Risk factors for non-arteritic ischaemic optic neuropathy in an Asian population

The authors reviewed the medical records of 45 Korean patients with non-arteritic anterior ischaemic optic neuropathy (NAION) and 45 healthy controls, in order to determine risk factors for the condition in an Asian population. Previous studies looking at risk factors...

Choroidal and macular thickness in nonarteritic anterior ischaemic optic neuropathy

This study evaluates the choroidal and macular thickness in patients with chronic nonarteritic anterior ischaemic optic neuropathy (NA-AION). Two groups of subjects were compared, group one included 20 eyes with chronic NA-AION and group two, 31 healthy control eyes. The...

Investigation of blood platelet parameters in anterior ischaemic optic neuropathy

The aim of this clinical retrospective comparative study was to assess the possible relationship between arteritic anterior ischaemic optic neuropathy (AAION) and non-arteritic anterior ischaemic optic neuropathy (NAION) with blood platelet parameters and neutrophil-to-lymphocyte ratio (NLR). The medical records of...

A novel way to distinguish between types of anterior ischaemic optic neuropathy

The authors evaluate the monocyte to high-density lipoprotein (HDL) ratio (MHR) in patients with arteritic and non arteritic anterior ischaemic optic neuropathy (A-AION / NA-AION). A distinction between the two types of AION is essential to begin appropriate treatment, which...

Unusual case presentation of arteritic anterior ischaemic optic neuropathy

The authors present a single case of an 84-year-old man with arteritic anterior ischaemic optic neuropathy, but with unusual features on temporal artery biopsy. He presented with a three-day history of sudden onset of loss of vision in his right...

Visual prognosis in Irish Leber’s hereditary optic neuropathy

Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...

A review of the risk of nonarteritic anterior ischaemic optic neuropathy post-cataract surgery

A systematic review and meta-analysis are presented with the aim of assessing whether cataract surgery increases the risk of non-arteritic anterior ischaemic optic neuropathy (NAION) and identify potential predictors of risk. The search strategy components are outlined in detail. A...

Leber’s hereditary optic neuropathy: from lab to clinic

Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Comparison of central laminar thickness in optic neuropathy and normal eyes

The study compares central laminar thickness (LT) among patients with glaucomatous optic neuropathy (GON), patients with non-GON and normal subjects. The non-GON group comprised eyes with demyelinating optic neuropathy (ON), anterior ischaemic ON, compressive ON, Leber hereditary ON and traumatic...