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Eye Capacity: clinical need should drive ophthalmic service provision
Almost two million people in the UK suffer sight loss, a number forecast to double over coming decades. Major causes of blindness are age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, cataract and uncorrected refractive error. Prevalence of these sight-threatening conditions...NICE drugs: an update on what’s good to go
Treatment options recommended by the National Institute for Health and Care Excellence (NICE) must be readily available for use in the NHS of England and Wales. This article provides an overview of recent guidance from NICE and summary advice issued...Pathophysiology of diabetic macular oedema: why combination therapy may be better
The prevalence of diabetes has continued to increase over the years. It is currently estimated that there are 382 million with diabetes worldwide in 2013, and that this figure is expected to rise to 592 million by 2035 [1]. In...Lessons from an unusual case of syphilis
The rise of syphilis transmission rates over the past two decades has been one of public health’s great puzzles. In the UK, the situation has reached epidemic levels, with a 126% increase between 2013 and 2018 [1]. We present a...Moorfields Eductation: ocular oncology for the non-ocular oncologist: what you need to know for clinical practice
This brand new course is aimed at ophthalmologists, trainees, optometrists and medical retina specialists and will cover the following topics: How to assess and diagnose ocular tumoursHow to refer patients to an ocular oncology centreUse of the MOLES score for...Assessing everyday visual function in dry AMD – what matters to the person?
Age-related macular degeneration (AMD) is the primary cause of blindness in the developed world and is accountable for more than one half of sight impairment registrations within England and Wales [1]. AMD is prevalent in people aged 60 years and...Development of retinoblastoma services in Zimbabwe
Zimbabwe recognised the need for a paediatric ophthalmology service almost 20 years ago. The economic uncertainty in the country made it difficult to secure financial support, so initial funding came through local donors. Equipment – including vision charts, ophthalmoscopes and...The clues of the eye – what is medical ophthalmology?
The author looks at the increasingly significant role of medical ophthalmologists and the importance of integrative healthcare. The eye is a remarkable organ, and for decades we have been discovering intimations of pathology existing elsewhere in the body [1] simply...
Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...
Retinoblastoma risk factors for recurrence
This study evaluates risk factors for local tumour recurrence of main solid tumour, subretinal seed, vitreous seed and new tumour formation in eyes with retinoblastoma (RB) management with primary chemotherapy over 20 years of follow-up. The study included 960 eyes...
Germline mutation risk in solitary unilateral retinoblastoma
This study aimed to determine the true risk for germline mutation in a child presenting with solitary unilateral RB and whether this risk differs by age at presentation. This was a retrospective review of 482 cases from 1972-2020. Age groups...
