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Intravitreal Ziv-Aflibercept: safety analysis
Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...
Inflammation and microvascular changes in diabetic retinopathy
Studies have shown that neurodegeneration and inflammation in the retina start early in diabetic retinopathy (DR) and can be present before the latter is clinically evident. The aim of this retrospective review of 99 diabetic patients was to evaluate retinal...
Exploring the potential of neurodegenerative disease screening within age-related eye disease research
The authors recruited healthy controls aged between 60 and 75-years-old, previously enrolled into a registry as patients following cataract surgery without age-related macular degeneration (AMD). Exclusion criteria included dense cataract, retinal disease, ocular inflammatory disease, moderate glaucoma, optic neuropathy, cancer,...
Patient reported outcomes in adolescents with inherited retinal diseases
This was a two-centre validation study of two sets of patient reported outcome measures (PROMS) for adolescents (13-17- years-old) with inherited retinal diseases. The measures were the Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ). Both...Help the VISION 2020 LINKS & Networks Programme to save children’s sight and lives
The LINKS & Networks Programme was established at the International Centre for Eye Health (ICEH), London School of Health and Tropical Medicine (LSHTM), 20 years ago to improve the quality and quantity of eye health services in low- and middle-income...My top five Apps for UK-based general ophthalmologists
The way we interact in society is changing as more of us are becoming ‘digital natives’: individuals who are in close contact to the internet and expect to integrate smart devices with our daily lives. This was stereotypically a term...My Top Five: Apps for UK-based general ophthalmologists
The way we interact in society is changing as more of us are becoming ‘digital natives’: individuals who are in close contact to the internet and expect to integrate smart devices with our daily lives. This was stereotypically a term...In conversation with Robert MacLaren
Professor Robert MacLaren gave the Keeler Lecture at the Royal College of Ophthalmologists Annual Meeting in May 2019 on gene therapy for retinitis pigmentosa. We caught up with him afterwards to find out more. What are the key messages of...
