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DMEK versus DSAEK
This systematic review and meta-analysis reviewed published evidence comparing two endothelial corneal transplants techniques; Descemet membrane endothelial keratoplasty (DMEK) and Descemet stripping automated endothelial keratoplasty (DSEAK). DMEK involves transplanting Descemet membrane with endothelial cells without any overlying stroma. In DSAEK...
DSEK – five year results
This UK based study examined long-term descemet stripping endothelial keratoplasty (DSEK) results, looking at graft survival and endothelial cell losses. Data on 210 grafts were included in analysis. Most frequent indication for DSEK was Fuch’s endothelial dystrophy (81.4%) and 46.3%...
Risks factors for graft preparation failure in DMEK
Diabetes mellitus (DM) makes it more difficult to prepare descemet membrane epithelial keratoplasty (DMEK) grafts due to the ‘stickiness’ of Descemet’s membrane. This retrospective study examined a classification system, where donors were scored points according to their DM related risk...
Froben for anterior scleritis
Flurbiprofen (Froben) is one of the nonselective cyclooxygenase (COX) inhibitors blocking both COX-1 and COX-2 pathways. Agrawal et al. undertook a retrospective cohort study to determine the effectiveness of oral Froben in managing noninfectious, non-necrotising anterior scleritis. One hundred and...
Effects of orbital decompression
This is a retrospective review of 319 orbital decompression operations in 169 patients (73% female) with thyroid eye disease. Three wall decompressions were performed in 92 eyes, 2-wall in 206 (medial and floor), and a single wall (medial) in 18,...
Tacrolimus for endothelial rejection
This double-blinded randomised controlled trial tested the use of adjuvant topical Tacrolimus drops in cases of acute endothelial rejection in penetrating keratoplasty (PK). Patients with typical signs of endothelial rejection were randomised to receive either steroid therapy with topical Tacrolimus...
Aflibercept, bevacizumab or ranibizumab for diabetic macular oedema
Macular oedema (MO) is a leading cause of visual impairment in patients with diabetic retinopathy. Whilst laser photocoagulation therapy has been the proven treatment for decades, studies over the last five years have also established a role for anti-VEGF agents...
Do topical steroids improve visual outcome in the treatment of bacterial keratitis?
The use of topical corticosteroids as an adjunctive treatment to antibiotics in the management of bacterial keratitis remains a controversial issue. The results of the Steroids for Corneal Ulcers Trial (SCUT) – a randomised, double-masked, placebo-controlled trial that recruited patients...
Effect of change in retinal nerve fibre layer thickness on quality of life in patients with glaucoma
The authors investigated the relationship between structural changes in glaucoma (retinal nerve fibre layer (RNFL) thickness) and quality of life (as measured by the NEI VFQ-25 questionnaire) over a period of time. Two hundred and sixty eyes of 130 patients...
Comparison between findings in OCTA and FA in patients with diabetic retinopathy
In this study the authors present a prospective cross-sectional comparative study of typical findings of diabetic retinopathy to analyse the agreement between the image modalities of optical coherence tomography angiography (OCTA) and fluorescein angiography (FA). Fifty-three eyes of 42 patients...
Neurofibromatosis type 1 features
The aim in this study was to identify the incidence and de nova mutation rate of Neurofibramatosis type 1 (NF1) and describe the ocular and non-ocular findings in a population-based cohort of patients diagnosed over a 30-year period. The study...
