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World-first artificial intelligence foundation model for eye care to supercharge global efforts to prevent blindness

22 September 2023 | oculomics, AI, moorfields, big data, RETFound, ChatGPT, UCL, artificial intelligence
Researchers at Moorfields Eye Hospital and UCL Institute of Ophthalmology (IoO) have developed an artificial intelligence (AI) system that has the potential to not only identify sight-threatening eye diseases but also predict general health, including heart attacks, stroke and Parkinson’s disease.

Protecting retinal ganglion cells

1 August 2017 | | EYE - Glaucoma
Glaucoma is considered to be a heterogeneous group of conditions giving retinal ganglion cells (RGC) damage. Lowering intraocular pressure (IOP) reduces the risk of progressive RGC loss in glaucoma. Regeneration of the optic nerve has been shown to restore some...

Stereotactic radiotherapy for polypoidal choroidal vasculopathy

1 August 2015 | | EYE - Vitreo-Retinal
Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular AMD. It is a disease of choroidal vasculature characterised by abnormal branching vascular network with aneurysmal dilatations (polyps). Features of PCV include pigment epithelial detachments (PED), subretinal fluid (SRF) accumulation and...

Clinical trial investigates ‘Light Touch’ approach to wet AMD treatment

20 October 2025 | NIHR, Treatment, Retina, neovascularisation, vision
A clinical trial led by NIHR Moorfields Clinical Research Facility will explore a new ‘light-touch’ treatment approach for patients with neovascular age-related macular degeneration (wet AMD) that could result in fewer injections and reduced number of clinic visits. Funded by...

Demystifying external trainee selected components and out of programme experiences

3 February 2023 | | EYE - General
If you don’t know your external TSCs from your OOPC/OOPT/OOPE/OOPR, then this article is for you. Trainee selected components (TSC) are College-approved periods of training, usually ranging from six months to a year (formally ASTO) of intensive subspecialty training in...

Strabismus and ocular motility, demystified

3 April 2024 | | EYE - Paediatrics, EYE - Strabismus, EYE - General
I am a former orthoptist, now trained in medicine and working as a foundation doctor. In my previous work, I was frequently approached by ophthalmology trainees eager for guidance with strabismus and ocular motility. Drawing on my clinical experience, I...

Exploiting nature’s randomised trials of eye disease

1 December 2022 | | EYE - Glaucoma, EYE - Vitreo-Retinal, EYE - Orbit
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...

Congenital cranial dysinnervation disorders (CCDDs)

3 October 2022 | | EYE - General
The term congenital cranial dysinnervation disorder (CCDD) was introduced by Gutowski et al. in 2003 to describe strabismus conditions that result from developmental error in innervation of some of the extraocular muscles. Examples of these conditions include Duane’s syndrome and...

Non-infectious Uveitis: Well Known, Weird and Wonderful meets You, Me and the Balloons

3 August 2023 | | EYE - Vitreo-Retinal
Installation view from Manchester International Festival 2023 exhibition Yayoi Kusama: You, Me and the Balloons at Aviva Studios. Images © David Levene. On an uncharacteristically salubrious 5 July 2023, the date of the 75th Anniversary of the UK’s NHS, a...

From paper to pocket: Standardising eyecare with the Malawi Eye Care App

4 December 2025 | | EYE - General
Malawi’s population is mostly rural; the government and Christian Health Association of Malawi (CHAM) together deliver about 80% of healthcare services through local district and community health facilities [1]. However, ophthalmology specialist services are only concentrated in the central hospitals....

Bovine pericardium scleral patch graft associated scleritis: Ahmed valve implant for pupillary block glaucoma

1 April 2016 | | EYE - Glaucoma, EYE - General
Processed bovine pericardium is a lyophilised collagen sheet used as a surgical armamentarium. It renders the material antigenically inert with minimal inflammation [1]. Sclera patch pericardium graft (Tutopatch) is a collagenous membrane derived from solvent preserved, irradiated bovine pericardium [2]...

Oculogyric crisis with B12 deficiency

1 June 2022 | | EYE - Neuro-ophthalmology, EYE - Imaging, EYE - General
An oculogyric crisis (OGC) is a dystonic movement disorder of the eyes which can last from seconds to hours. Although there is no published diagnostic criteria for OGC, typically the onset is acute, and it is characterised by conjugate upward...