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The 2020 Milgram Experiment
19 May 2020
| Gwyn Samuel Williams
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EYE - General
Will ophthalmology recover from COVID-19? Learning Curve columnist Gwyn Samuel Williams shares his thoughts on the developing impact of the pandemic “It’s busy today,” the nurse in green chuckles. “There are six patients I think.” Six. This clinic is designed...
Laissez-faire approach for medial canthus tumours
This is a retrospective comparative case series of patients who underwent reconstruction of a medial canthal defect using laissez-faire approach (LFS), or a full-thickness skin graft (FTSG). The surgical options were discussed with the patient and the treatment decision was...Cataract surgery in uveitis
This is a multicentre study of eight UK independent sites of patients with uveitis, undergoing cataract surgery between January 2010 and December 2014. A total of 1173 eyes were compared with a control reference group of 95,573 eyes from the...Online retinoblastoma surveillance tool
7 December 2020
| Annes Ahmeidat
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EYE - Pathology, EYE - Oncology
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Familial relationship, Genetics, Retinoblastoma, Surveillance
Given the vision and life-threatening course of retinoblastoma (RB), it has become a significant heritable childhood cancer to screen for. To recommend surveillance, risk must be estimated and genetic testing plays a vital role. However, genetic tests vary based on...
Unravelling ocular motility
1 April 2016
| Damien CM Yeo
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EYE - Neuro-ophthalmology
Ocular motility can often be a slightly abstract concept during the earlier years of ophthalmology training. A large variance on what embodies normality; mythical concepts like fusion and binocular vision, examination techniques that can be fiddly, and complex neuroanatomy all...
The assessment of pupils and pupillary reactions
1 October 2015
| Li Yen Goh
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EYE - Vitreo-Retinal
Understanding pupillary reactions is vital in understanding basic neuro-opthalmology. It is a skill required in eye casualty, clinics and perhaps most importantly, exams. To start at the beginning, the pupil is the central aperture of the iris, its size controlling...
Differential inhibition of EAU by CTLA4 and IL-6
1 February 2016
| Graham Wallace
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EYE - Vitreo-Retinal
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
PD-1 and PD-L1 in exenteration specimens
This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...Breakthroughs in the genetics of angle-closure glaucoma
1 April 2017
| Sancy Low, Paul J Foster (Prof)
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EYE - Glaucoma
Angle closure glaucoma (ACG) is not widely known to be a familial condition, yet the recent explosion of genetic data and large scale genome wide investigations have confirmed at least 13 genetic loci associated with ACG [1], and provided some...
What's trending Feb/Mar 2022
A round-up of the eye-related hot topics that have been trending over the last few weeks. British man fitted with 3D printed eye Steve Verze of London has required a prosthetic eye for over 20 years. On 25 November 2021,...Life as a Global Citizen Consultant Ophthalmologist: a personal view of working in Scotland and Tanzania
3 October 2022
| Rosie Brennan, Bernadetha Robert Shilio, Marcia Zondervan, Covadonga Bascaran
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EYE - General
Global Citizen post - a new challenge I was looking for a new challenge. I had been in the same consultant post with a subspecialty interest in paediatrics and strabismus for 17 years and was rattling around in an empty...
Transsynaptic retrograde degeneration linked to homonymous visual field loss after stroke
10 May 2024
| Lauren R Hepworth
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EYE - Neuro-ophthalmology
centre, of individuals identified with homonymous visual field loss post ischaemic stroke. Exclusion criteria were bilateral ischaemia, anterior / pregeniculate visual pathway affected and other pathology with the potential to effect visual fields. The following were extracted from the medical...