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Understanding optic nerve head pericytes and glaucoma

The authors provide a comprehensive review of the current understanding of pericytes in the optic nerve head (ONH). Key points include: (1) Pericytes are contractile mural cells that play crucial roles in regulating blood flow, maintaining the blood-brain / blood-retinal...

Efficacy and safety of intravitreal faricimab in nAMD, DME and RVO

This paper is an analysis of data extracted from 13 eligible studies in the context of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO), collected from systematic literature search of MEDLINE, Embase, and Cochrane...

Clinical trial investigates ‘Light Touch’ approach to wet AMD treatment

A clinical trial led by NIHR Moorfields Clinical Research Facility will explore a new ‘light-touch’ treatment approach for patients with neovascular age-related macular degeneration (wet AMD) that could result in fewer injections and reduced number of clinic visits. Funded by...

The ocular manifestations of COVID-19: an overview of current literature

Although respiratory symptoms are the most frequent manifestation of COVID-19, multi-organ involvement has been demonstrated, including ocular manifestations. The author investigates how the eye can be affected. The SARS-CoV-2 virus responsible for the COVID-19 pandemic has presented a significant public...

UKEGS (UK and Éire Glaucoma Society) Conference 2024

Pretty soon it’s going to be the 9th of October, and a quick Wikipedia search will tell you of how this day in history has seen the founding of the Kingdom of Valencia, the initial whispers of the Prague Astronomical...

High-stakes scenarios in retinal vein occlusion: A survey of medico-legal implications

Central retinal vein occlusion (CRVO) is the second most common retinal vascular disease after diabetic retinopathy, and its clinical complexity often intersects with medico-legal scrutiny [1]. Missteps in timely diagnosis, inadequate follow-up or poor documentation can lead to patient harm...

Developments in Ophthalmology: Ophthalmic Radiation Therapy Techniques and Applications

Radiation was discovered by Wilhelm Roentgen in 1895, and since then has been used to treat a variety of cancers. Its therapeutic properties have been widely used for ocular and periocular tumours and inflammatory disease, but the present era is...

Ophthalmology (third edition)

If you are an ophthalmologist who enjoys books with coloured pictures, you’re no lone wolf. The third edition of Lang’s Ophthalmology will definitely pique your primal ophthalmologist instincts. You will be drawn to its soft-bound yet sturdy looking exterior. Flicking...

Paediatric uveitis in India

This article was a retrospective review of paediatric patients presenting to a tertiary hospital in India. Records over a three year period were reviewed. The authors highlight that children account for about 2.2-13.8% of uveitis patients and are at greater...

Treat-and-extend regimen in treatment of patients with type 3 neovascularisation

Type 3 neovascularisation, also known as retinal angiomatous proliferation is a distinct subtype of neovascular AMD characterised by intraretinal neovascularisation. This retrospective study included 17 eyes diagnosed with type 3 neovascularisation who were changed from pro-re-nata (PRN) based treatment regime...

Broadening of treatment options for potentially blinding retinal conditions

Rod McNeil provides an update on a promising bispecific antibody recently approved for treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO) and considers emerging developments in biosimilars to established anti-vascular endothelial growth factor (anti-VEGF) therapies, including...

Treatment of diabetic macular oedema

Diabetic macular oedema (DMO) is a common complication associated with diabetic retinopathy, and the most common cause of visual impairment in diabetes [1]. With predicted rising levels of diabetes (in England by 2025 the estimated population with diabetes will be...