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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...It’s not always GCA
Giant cell arteritis (GCA) is an immune mediated granulomatous inflammatory disease that affects muscular middle or large sized arteries. It is considered as a continuation of polymyalgia rheumatica (PMR) when the severity of the disease has increased. It is the...Neurofibromatosis type 2 – diagnosis, features and MDT approach
NF2 is a genetic condition caused by mutation in a single gene (NF2 gene) on chromosome 22. The NF2 gene provides instructions to produce a protein called merlin, also known as schwannomin. This protein functions as a tumour suppressor, preventing...The results of the last survey Feb25
*Please be aware that this data does not form part of a peer reviewed research study. The information therein should not be relied upon for clinical purposes but instead used as a guide for clinical practice and reflection. The sample...An uncommon late postoperative complication of combined cataract surgery and intravitreal triamcinolone injection
Case report A 64-year-old female with diabetic maculopathy (DMO) underwent phacoemulsification with intraocular lens (IOL) implantation in her right eye combined with intravitreal triamcinolone (IVTA). Diabetes control was poor with HbA1c (IFCC) of 119mmol/mol and blood sugar level of 27mmol/L....A unique case of macular burn from ‘toy’ laser
The first laser was created in 1960 and its name is an acronym for ‘light amplification by stimulated emission of radiation’. Laser technology has been used for medical, industrial, research and entertainment purposes in a variety of fields following extensive...It’s Friday, I’m In Love: Pete’s Hidden Curriculum Part 3
“When you’re in love, it’s the most glorious two-and-a-half days of your life.” - Richard Lewis [1]. The good news is that we are over the hump now and past the most depressing day of the year, which is known...Congenital cataract
Congenital cataract is the clouding or opacification of the lens that occurs at birth or weeks after (infantile cataract). They can be unilateral or bilateral and vary in form, size and location, and consequently the visual impact, management course and...What's trending Dec/Jan 2026
A round-up of the eye-related hot topics that have been trending on social media over the last few weeks. #SciFi #Vision Growing up at home, it was my job to read the crossword clues out to my parents. I usually...Pathophysiology of diabetic macular oedema: why combination therapy may be better
The prevalence of diabetes has continued to increase over the years. It is currently estimated that there are 382 million with diabetes worldwide in 2013, and that this figure is expected to rise to 592 million by 2035 [1]. In...Tough gig
‘The times they are a-changin’. The words of this Dylan classic resonate down the decades, and in the light of recent events, speak eloquently to life in 2022. It feels like a lifetime of change has passed since the Eye...
